WEKO3
アイテム
Evaluation of prostaglandin E2 and E-series prostaglandin receptor in patients with interstitial cystitis
https://asahikawa-med.repo.nii.ac.jp/records/5512
https://asahikawa-med.repo.nii.ac.jp/records/551229fa0574-d361-4e80-8680-52aeb8b29ac6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6523.pdf (354.3 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-08-16 | |||||
| タイトル | ||||||
| タイトル | Evaluation of prostaglandin E2 and E-series prostaglandin receptor in patients with interstitial cystitis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cystitis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | dinoprostone | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | etiology | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | interstitial | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | prostaglandin E | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | receptors | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | urinary bladder | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
和田, 直樹
× 和田, 直樹× 飴田, 要× 古野, 剛史× 岡田, 啓希× 伊達, 一郎× 柿崎, 秀宏 |
|||||
| 著者 ローマ字 | ||||||
| 値 | Wada, Naoki | |||||
| 著者 ローマ字 | ||||||
| 値 | Ameda, Kaname | |||||
| 著者 ローマ字 | ||||||
| 値 | Furuno, Tsuyoshi | |||||
| 著者 ローマ字 | ||||||
| 値 | Okada, Hiroki | |||||
| 著者 ローマ字 | ||||||
| 値 | Date, Ichiro | |||||
| 著者 ローマ字 | ||||||
| 値 | Kakizaki, Hidehiro | |||||
| 書誌情報 |
The Journal of urology 巻 193, 号 6, p. 1987-1993, 発行日 2015-06-01 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0022-5347 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.juro.2015.01.010 | |||||
| 識別番号 その他 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PMID:25595860 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | PURPOSE: \nWe evaluated PGE2 and EP receptor in patients with interstitial cystitis. MATERIALS AND METHODS: \nEnrolled in the study were 20 female patients with interstitial cystitis (11 with and 9 without Hunner lesions), 9 female controls with another urological disease who needed a cystoscopic procedure and 10 normal volunteers. In all participants we determined O'Leary-Sant symptom and problem scores, and obtained voluntary urine specimens for PGE2 analysis. Using anesthesia the bladder was distended by saline in stepwise fashion from 100 ml to maximum capacity in patients with interstitial cystitis. Each time the infused saline was retrieved for PGE2 analysis. We also measured PGE2 and the expression of EP receptor mRNA in bladder biopsy tissue in patients with interstitial cystitis. RESULTS: \nSymptom and problem indexes in patients with interstitial cystitis and Hunner lesions were significantly higher than in patients with interstitial cystitis without Hunner lesions. Urinary PGE2 in patients with interstitial cystitis and Hunner lesions was significantly higher than in patients with interstitial cystitis without lesions, controls and normal volunteers. PGE2 in retrieved saline in patients with interstitial cystitis and Hunner lesions increased depending on infusion volume but not in patients with interstitial cystitis without lesions. PGE2 content in bladder biopsy tissue was significantly higher in patients with interstitial cystitis and Hunner lesions than in controls. In patients with interstitial cystitis and Hunner lesions the expression of EP1 and EP2 mRNA was significantly higher than in controls. CONCLUSIONS: \nOur study showed increased PGE2 production and mRNA expression of EP1 and EP2 receptors in the bladder in patients with interstitial cystitis and Hunner lesions. Further studies are warranted to explore the pathophysiological and therapeutic implications. |
|||||
| 注記 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | CC-BY-NC-ND | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| ID(XooNIps) | ||||||
| 値 | 25595860 | |||||
| 閲覧数(XooNIps) | ||||||
| 値 | 557 | |||||
| ダウンロード数(XooNIps) | ||||||
| 値 | 1820 | |||||
