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Improvement of Overactive Bladder Symptoms and Bladder Ischemia with Dutasteride in Patients with Benign Prostatic Enlargement.
https://asahikawa-med.repo.nii.ac.jp/records/5511
https://asahikawa-med.repo.nii.ac.jp/records/551126c54e4a-2a6f-4078-b31d-549d4758ffc7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6522.pdf (313.0 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-08-16 | |||||
| タイトル | ||||||
| タイトル | Improvement of Overactive Bladder Symptoms and Bladder Ischemia with Dutasteride in Patients with Benign Prostatic Enlargement. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | benign prostatic hyperplasia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | bladder ischemia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | dutasteride | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | lower urinary tract symptoms | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | overactive bladder | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
和田, 直樹
× 和田, 直樹× 松本, 成史× 北, 雅史× 橋爪, 和純× 柿崎, 秀宏 |
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| 著者 ローマ字 | ||||||
| 値 | Wada, Naoki | |||||
| 著者 ローマ字 | ||||||
| 値 | Matsumoto, Seiji | |||||
| 著者 ローマ字 | ||||||
| 値 | Kita, Masafumi | |||||
| 著者 ローマ字 | ||||||
| 値 | Hashizume, Kazumi | |||||
| 著者 ローマ字 | ||||||
| 値 | Kakizaki, Hidehiro | |||||
| 書誌情報 |
Lower urinary tract symptoms 巻 7, 号 1, p. 37-41, 発行日 2015-01-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1757-5664 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/luts.12047 | |||||
| 識別番号 その他 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PMID:26663650 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | OBJECTIVES: \nTo evaluate the correlation of clinical and urodynamic parameters with bladder vascular resistance before and after dutasteride treatment in patients with lower urinary tract symptoms associated with benign prostatic enlargement. METHODS: \nA prospective study was conducted in 30 consecutive patients with benign prostatic enlargement who had not been satisfied with alpha-adrenergic antagonist monotherapy. Before and 24 weeks after dutasteride add-on treatment, we assessed International Prostate Symptom Score (IPSS), prostate volume (PV), urodynamic study and contrast-enhanced color Doppler ultrasonography to measure bladder vascular resistive index (RI). RESULTS: \nTwenty-four weeks after dutasteride, PV significantly decreased from 68 ± 29 to 48 ± 28 mL (P < 0.001), and there was significant improvement of IPSS (from 18.8 ± 7.7 to 13.4 ± 7.2, P < 0.001). Urgency score of IPSS was also significantly improved from 2.3 ± 1.9 to 1.4 ± 1.4 (P < 0.01) after dutasteride. On pressure-flow study, bladder outlet obstruction index (BOOI) (from 58 ± 36 to 38 ± 27, P < 0.001) and detrusor pressure at Qmax (PdetQmax) (from 73 ± 34 to 54 ± 25 cmH2 O, P < 0.001) were significantly improved. RI significantly decreased after dutasteride (from 0.548 ± 0.069 to 0.486 ± 0.064, P < 0.001). In 20 patients with persistent urgency after dutasteride, RI was less improved than in another 10 patients without urgency (change of RI 0.045 ± 0.091 vs. 0.096 ± 0.042, P < 0.05). Post-treatment BOOI and PdetQmax in patients with persistent urgency was significantly higher than in those without urgency after dutasteride (BOOI: 46 ± 28 vs. 24 ± 20, P < 0.05, PdetQmax: 62 ± 26 vs. 40 ± 17 cmH2 O, P < 0.01). CONCLUSIONS: \nReduction of obstruction and improvement of bladder ischemia might play an important role in a beneficial impact of dutasteride on overactive bladder symptoms. |
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| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| ID(XooNIps) | ||||||
| 値 | 26663650 | |||||
| 閲覧数(XooNIps) | ||||||
| 値 | 713 | |||||
| ダウンロード数(XooNIps) | ||||||
| 値 | 526 | |||||
