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Five-Year Experience with Risedoronate Therapy for Patients with Increased Fracture Risk: A Practice-Based Observational Study
https://asahikawa-med.repo.nii.ac.jp/records/5503
https://asahikawa-med.repo.nii.ac.jp/records/5503d05c4a6a-0047-4a69-ae51-a194d82c3f21
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6507.pdf (514.5 kB)
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| Item type | 学位論文 / Thesis or Dissertation_02(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2016-07-13 | |||||||||
| タイトル | ||||||||||
| タイトル | Five-Year Experience with Risedoronate Therapy for Patients with Increased Fracture Risk: A Practice-Based Observational Study | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | risedronate | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | geometry | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | bone mineral density | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | advanced hip assessment | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | femur strength index | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| タイトル カナ | ||||||||||
| その他のタイトル | 骨折リスクが高い患者を対象としたリセドロネートの5年間の治療成績－実臨床下における観察研究－ | |||||||||
| 著者 |
高桑, 昌幸
× 高桑, 昌幸
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| 著者 ローマ字 | ||||||||||
| Takakuwa, Masayuki | ||||||||||
| 書誌情報 |
Biological and pharmaceutical bulletin 巻 38, 号 1, p. 88-95, 発行日 2015-01-01 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0918-6158 | |||||||||
| DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | http://dx.doi.org/10.1248/bpb.b14-00592 | |||||||||
| 識別番号 その他 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | PMID:25744463 | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 乙464 | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2016-06-30 | |||||||||
| 学位名 | ||||||||||
| 学位名 | 博士（医学） | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関名 | 旭川医科大学 | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | The purpose of this practice-based observational study was to examine the effects of long-term treatment with risedronate in patients with an increased fracture risk. Seventy patients (4 men and 66 postmenopausal women; mean age, 68.0 years) with osteoporosis or osteopenia and clinical risk factors for fractures were treated with risedronate at either 2.5 mg/d or 17.5 mg/week for 5 years. The bone mineral density (BMD) of the lumbar spine and proximal femur, and the structural geometric parameters of the proximal femur were evaluated by dual-energy X-ray absorptiometry with advanced hip assessment software at baseline and after each year of treatment. The lumbar spine BMD rapidly increased during the first year of the treatment and steadily increased throughout the 5-year treatment period. The BMD of the femoral neck and total hip also significantly increased during the first 3 and 2 years of treatment, respectively, then gradually declined and reached the baseline level after 5 years of treatment. The cross-sectional moment of inertia, cross-sectional area, and mean width of the femoral neck region of interest significantly increased during the first 2 years, and these increases were maintained throughout the 5-year treatment period. The femur strength index and section modulus also significantly increased following time courses similar to those of the above three parameters. These results suggest that risedronate produced both a sustained increase in the lumbar spine BMD and improvement in the femoral structural geometric parameters for 5 years of treatment. | |||||||||
| 資源タイプ | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
