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Polyphosphate Derived from Lactobacillus brevis Inhibits Colon Cancer Progression Through Induction of Cell Apoptosis
https://asahikawa-med.repo.nii.ac.jp/records/5502
https://asahikawa-med.repo.nii.ac.jp/records/550241319d7b-6ffa-41a3-a76c-3e905aa46bbb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6506.pdf (450.8 kB)
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| Item type | 学位論文 / Thesis or Dissertation_02(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-07-13 | |||||
| タイトル | ||||||
| タイトル | Polyphosphate Derived from Lactobacillus brevis Inhibits Colon Cancer Progression Through Induction of Cell Apoptosis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Colon cancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ERK | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | antitumor effect | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | apoptosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | polyphosphate | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | probiotics | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| タイトル カナ | ||||||
| その他のタイトル | Lactobacillus brevis由来ポリリン酸によるアポトーシス誘導を介した大腸癌抑制作用に関する研究 | |||||
| 著者 |
坂谷, 慧
× 坂谷, 慧 |
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| 著者 ローマ字 | ||||||
| 値 | Sakatani, Aki | |||||
| 書誌情報 |
Anticancer research 巻 36, 号 2, p. 591-598, 発行日 2016-02-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0250-7005 | |||||
| 識別番号 その他 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PMID:26851013 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲497 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2016-06-30 | |||||
| 学位名 | ||||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 10107 | |||||
| 学位授与機関名 | 旭川医科大学 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Although probiotics are known to have antitumor activity, few bacteria-derived antitumor molecules have been identified. The present study explored an antitumor molecule derived from Lactobacillus brevis SBL8803 (L. brevis 8803) and the mechanisms that underlie its effects. Cell viability and apoptosis were assessed by a sulforhodamine B assay and terminal deoxynucleotidyl transferase dUTP staining, respectively. Phosphorylated extracellular signal-regulated kinase (ERK) and cleaved poly ADP-ribose polymerase (PARP) expression were detected by western blotting. The conditioned medium of L. brevis 8803 inhibited SW620 cells viability and the effect was reduced by the degradation of polyphosphate (poly P) in the conditioned medium. A xenograft model showed that poly P inhibited the growth of SW620 cells. Poly P induced the apoptosis of SW620 cells through activation of the ERK pathway. In contrast, in primary cultured cells derived from normal mouse, poly P did not affect cell viability. Probiotic-derived poly P is expected to be an antitumor drug with fewer adverse effects than conventional drugs. | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
