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CCL17 and CCL22/CCR4 signaling is a strong candidate for novel targeted therapy against nasal natural killer/T-cell lymphoma.
https://asahikawa-med.repo.nii.ac.jp/records/5500
https://asahikawa-med.repo.nii.ac.jp/records/5500ccddd0be-782d-44f4-b41b-93651d09dba0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6200.pdf (11.8 MB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-09-14 | |||||
| タイトル | ||||||
| タイトル | CCL17 and CCL22/CCR4 signaling is a strong candidate for novel targeted therapy against nasal natural killer/T-cell lymphoma. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CCR4 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CCL17 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CCL22 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Nasal NK/T-cell lymphoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Chemokine | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
熊井, 琢美
× 熊井, 琢美× 長門, 利純× 小林, 博也× 駒林, 優樹× 上田, 征吾× 岸部, 幹× 大栗, 敬幸× 高原, 幹× Esteban, Celis× 原渕, 保明 |
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| 著者 ローマ字 | ||||||
| 値 | Kumai, Takumi | |||||
| 著者 ローマ字 | ||||||
| 値 | Nagato, Toshihiro | |||||
| 著者 ローマ字 | ||||||
| 値 | Kobayashi, Hiroya | |||||
| 著者 ローマ字 | ||||||
| 値 | Komabayashi, Yuki | |||||
| 著者 ローマ字 | ||||||
| 値 | Ueda, Seigo | |||||
| 著者 ローマ字 | ||||||
| 値 | Kishibe, Kan | |||||
| 著者 ローマ字 | ||||||
| 値 | Ohkuri, Takayuki | |||||
| 著者 ローマ字 | ||||||
| 値 | Takahara, Miki | |||||
| 著者 ローマ字 | ||||||
| 著者 ローマ字 | ||||||
| 値 | Harabuchi, Yasuaki | |||||
| 書誌情報 |
Cancer Immunology, Immunotherapy 巻 64, 号 6, p. 697-705, 発行日 2015-06-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0340-7004 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s00262-015-1675-7 | |||||
| リンクURL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://link.springer.com/article/10.1007%2Fs00262-015-1675-7 | http://link.springer.com/article/10.1007%2Fs00262-015-1675-7 | |||||
| 識別番号 その他 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PMID:25754123 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Nasal natural killer/T-cell lymphoma (NNKTL) is associated with Epstein-Barr virus and has a poor prognosis because of local invasion and/or multiple dissemination. Various chemokines play a role in tumor proliferation and invasion, and chemokine receptors including the C-C chemokine receptor 4 (CCR4) are recognized as potential targets for treating hematologic malignancies. The aim of the present study was to determine whether specific chemokines are produced by NNKTL. We compared chemokine expression patterns in culture supernatants of NNKTL cell lines with those of other lymphoma or leukemia cell lines using chemokine protein array and ELISA. Chemokine (C-C motif) ligand (CCL) 17 and CCL22 were highly produced by NNKTL cell lines as compared to the other cell lines. In addition, CCL17 and CCL22 were readily observed in the sera of NNKTL patients. The levels of these chemokines were significantly higher in patients than in healthy controls. Furthermore, we detected the expression of CCR4 (the receptor for CCL17 and CCL22) on the surface of NNKTL cell lines and in tissues of NNKTL patients. Anti-CCR4 monoclonal antibody (mAb) efficiently induced antibody-dependent cellular cytotoxicity mediated by natural killer cells against NNKTL cell lines. Our results suggest that CCL17 and CCL22 may be important factors in the development of NNKTL and open up the possibility of immunotherapy of this lymphoma using anti-CCR4 mAb. | |||||
| 注記 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 著者最終原稿 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| ID(XooNIps) | ||||||
| 値 | 25754123 | |||||
| 閲覧数(XooNIps) | ||||||
| 値 | 620 | |||||
| ダウンロード数(XooNIps) | ||||||
| 値 | 485 | |||||
