| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2016-06-16 |
| タイトル |
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タイトル |
Levodopa acts centrally to induce an antinociceptive action against colonic distension through activation of D2 dopamine receptors and the orexinergic system in the brain in conscious rats. |
| 言語 |
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|
言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
Levodopa |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
Dopamine |
| キーワード |
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|
主題Scheme |
Other |
|
キーワード |
Orexin |
| キーワード |
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|
主題Scheme |
Other |
|
キーワード |
Antinociception |
| キーワード |
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|
主題Scheme |
Other |
|
キーワード |
Colonic distension |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
奥村, 利勝
野津, 司
粂井, 志麻
高草木, 薫
宮岸, 沙織
大平, 賀子
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| 著者 ローマ字 |
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Okumura, Toshikatsu |
| 著者 ローマ字 |
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Nozu, Tsukasa |
| 著者 ローマ字 |
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Kumei, Shima |
| 著者 ローマ字 |
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Takakusaki, Kaoru |
| 著者 ローマ字 |
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Miyagishi, Saori |
| 著者 ローマ字 |
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Ohhira, Masumi |
| 書誌情報 |
Journal of Pharmacological Sciences
巻 130,
号 2,
p. 123-127,
発行日 2016-02-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1347-8613 |
| DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.jphs.2016.01.007 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://www.sciencedirect.com/science/article/pii/S1347861316000086 | http://www.sciencedirect.com/science/article/pii/S1347861316000086 |
| 識別番号 その他 |
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内容記述タイプ |
Other |
|
内容記述 |
PMID:26883457 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Abstract
\nLevodopa possesses antinociceptive actions against several somatic pain conditions. However, we do not know at this moment whether levodopa is also effective to visceral pain. The present study was therefore performed to clarify whether levodopa is effective to visceral pain and its mechanisms. Visceral sensation was evaluated by colonic distension-induced abdominal withdrawal reflex (AWR) in conscious rats. Subcutaneously (80 mg/rat) or intracisternally (2.5 μg/rat) administered levodopa significantly increased the threshold of colonic distension-induced AWR in conscious rats. The dose difference to induce the antinociceptive action suggests levodopa acts centrally to exert its antinociceptive action against colonic distension. While neither sulpiride, a D2 dopamine receptor antagonist, nor SCH23390, a D1 dopamine receptor antagonist by itself changed the threshold of colonic distension-induced AWR, the intracisternally injected levodopa-induced antinociceptive action was significantly blocked by pretreatment with subcutaneously administered sulpiride but not SCH23390. Treatment with intracisternal SB334867, an orexin 1 receptor antagonist, significantly blocked the subcutaneously administered levodopa-induced antinociceptive action. These results suggest that levodopa acts centrally to induce an antinociceptive action against colonic distension through activation of D2 dopamine receptors and the orexinergic system in the brain. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
This is an open access
article under the CC BY-NC-ND license |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
VoR |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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26883457 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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|
814 |
6489.pdf (474.7 kB)
