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フリッカー光刺激後の網膜血流増加反応における Glia 細胞の役割
https://asahikawa-med.repo.nii.ac.jp/records/5418
https://asahikawa-med.repo.nii.ac.jp/records/5418741fed7d-42d3-40a9-9ac4-aee1ab81d621
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6395.pdf (552.5 kB)
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| Item type | 学位論文 / Thesis or Dissertation_02(1) | |||||||||
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| 公開日 | 2016-04-25 | |||||||||
| タイトル | ||||||||||
| タイトル | フリッカー光刺激後の網膜血流増加反応における Glia 細胞の役割 | |||||||||
| 言語 | ja | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| タイトル ローマ字 | ||||||||||
| その他のタイトル | Role of Glial Cells in Regulating Retinal Blood Flow during Flicker-Induced Hyperemia in Cats | |||||||||
| 著者 |
宋, 勇錫
× 宋, 勇錫
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| 著者 ローマ字 | ||||||||||
| Song, Yong-Seok | ||||||||||
| 書誌情報 |
Investigative Ophthalmology and Visual Science 巻 56, 号 12, p. 7551-7559, 発行日 2015-11-01 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0146-0404 | |||||||||
| DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1167/iovs.15-17676 | |||||||||
| 識別番号 その他 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | PMID:26618647 | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲495 | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2016-03-25 | |||||||||
| 学位名 | ||||||||||
| 学位名 | 博士（医学） | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関名 | 旭川医科大学 | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | PURPOSE: \nTo investigate how glial cells participate in retinal circulation during flicker stimulation in cats. METHODS: \nUsing laser Doppler velocimetry, we measured the vessel diameter and blood velocity simultaneously and calculated the retinal blood flow (RBF) in feline first-order retinal arterioles. Twenty-four hours after intravitreal injections of L-2-aminoadipic acid (LAA), a gliotoxic compound, and the solvent of 0.01 N hydrochloric acid as a control, we examined the changes in RBF in response to 16-Hz flicker stimulation for 3 minutes. We also measured the changes in RBF 2 hours after intravitreal injection of Nω-propyl-L-arginine (L-NPA), a selective neuronal nitric oxide synthase inhibitor, in LAA-treated eyes. To evaluate the effects of LAA on retinal neuronal function, ERGs were monitored. Immunohistochemical examinations were performed. RESULTS: \nIn LAA-treated eyes, histologic changes selectively occurred in retinal glial cells. There were no significant reductions in amplitude or elongation of implicit time in ERG after LAA injections compared with controls. In control eyes, the RBF gradually increased and reached the maximal level (53.5% ± 2.5% increase from baseline) after 2 to 3 minutes of flicker stimulation. In LAA-treated eyes, the increases in RBF during flicker stimulation were attenuated significantly compared with controls. In LAA-treated eyes 2 hours after injection of L-NPA, flicker-evoked increases in RBF decreased significantly compared with LAA-treated eyes. CONCLUSIONS: \nThe current results suggested that increases in RBF in response to flicker stimulation were regulated partly by retinal glial cells. |
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| 資源タイプ | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
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| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
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| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
