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Colorectal distention induces acute and delayed visceral hypersensitivity: role of peripheral corticotropin-releasing factor and interleukin-1 in rats
https://asahikawa-med.repo.nii.ac.jp/records/5397
https://asahikawa-med.repo.nii.ac.jp/records/5397db811f6c-7d65-4396-ac67-55832867e8fe
| 名前 / ファイル | ライセンス | アクション |
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6045.pdf (764.9 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||||||||||||
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| 公開日 | 2015-04-02 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | Colorectal distention induces acute and delayed visceral hypersensitivity: role of peripheral corticotropin-releasing factor and interleukin-1 in rats | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 著者 |
野津, 司
× 野津, 司
× 粂井, 志麻
× Miyagishi, Saori
× 高草木, 薫
× 奥村, 利勝
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| 著者 ローマ字 | ||||||||||||||||||||||||
| Nozu, Tsukasa | ||||||||||||||||||||||||
| 著者 ローマ字 | ||||||||||||||||||||||||
| Kumei, Shima | ||||||||||||||||||||||||
| 著者 ローマ字 | ||||||||||||||||||||||||
| 著者 ローマ字 | ||||||||||||||||||||||||
| Takakusaki, Kaoru | ||||||||||||||||||||||||
| 著者 ローマ字 | ||||||||||||||||||||||||
| Okumura, Toshikatsu | ||||||||||||||||||||||||
| 書誌情報 |
Journal of Gastroenterology p. 1153-1161, 発行日 2015-12-01 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 0944-1174 | |||||||||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||
| 関連識別子 | 10.1007/s00535-015-1070-3 | |||||||||||||||||||||||
| リンクURL | ||||||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||||||
| 内容記述 | http://link.springer.com/article/10.1007%2Fs00535-015-1070-3 | http://link.springer.com/article/10.1007%2Fs00535-015-1070-3 | |||||||||||||||||||||||
| 識別番号 その他 | ||||||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||||||
| 内容記述 | PMID:25808230 | |||||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||
| 内容記述 | BACKGROUND: \nMost studies evaluating visceral sensation measure visceromotor response (VMR) to colorectal distention (CRD). However, CRD itself induces visceral sensitization, and little is known about the detailed characteristics of this response. The present study tried to clarify this question. METHODS: \nVMR was determined by measuring abdominal muscle contractions as a response to CRD in rats. The CRD set consisted of two isobaric distentions (60 mmHg for 10 min twice, with a 30-min rest), and the CRD set was performed on two separate days, i.e., days 1 and 3, 8. RESULTS: \nOn day 1, VMR to the second CRD was increased as compared with that to the first CRD, which is the acute sensitization. VMR to the first CRD on day 3 returned to the same level as that to the first CRD on day 1, and total VMR, i.e., the whole response to the CRD set, was not different between day 1 and day 3. However, total VMR was significantly increased on day 8 as compared with that on day 1, suggesting CRD induced the delayed sensitization. Intraperitoneally administered astressin (200 µg/kg), a corticotropin-releasing factor receptor antagonist, at the end of the first CRD blocked the acute sensitization, but anakinra (20 mg/kg, intraperitoneally), an interleukin-1 receptor antagonist, did not modify it. Astressin (200 µg/kg, twice before CRD on day 8) did not alter the delayed sensitization, but anakinra (20 mg/kg, twice) abolished it. CONCLUSIONS: \nCRD induced both acute sensitization and delayed sensitization, which were mediated through peripheral corticotropin-releasing factor and interleukin-1 pathways, respectively. |
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| 注記 | ||||||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||||||
| 注記 | 著者最終版 "The final publication is available at link.springer.com" \nEpub 2015 Mar 26 |
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| 内容記述タイプ | Other | |||||||||||||||||||||||
| 資源タイプ | text | |||||||||||||||||||||||
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| 出版タイプ | AM | |||||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||||||||||
| ID(XooNIps) | ||||||||||||||||||||||||
| 25808230 | ||||||||||||||||||||||||
| 閲覧数(XooNIps) | ||||||||||||||||||||||||
| ダウンロード数(XooNIps) | ||||||||||||||||||||||||
| 677 | ||||||||||||||||||||||||
