| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2016-03-15 |
| タイトル |
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タイトル |
In vivo analysis of kallikrein-related peptidase 6 (KLK6) function in oligodendrocyte development and the expression of myelin proteins. |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
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キーワード |
protease |
| キーワード |
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主題Scheme |
Other |
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キーワード |
spinal cord |
| キーワード |
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主題Scheme |
Other |
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キーワード |
development |
| キーワード |
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主題Scheme |
Other |
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キーワード |
myelin |
| キーワード |
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主題Scheme |
Other |
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キーワード |
spinal cord injury |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
村上, 公一
Ying-Ping, Jiang
田中, 達英
板東, 良雄
Branka, Mitrovic
吉田, 成孝
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| 著者 ローマ字 |
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Murakami, Koichi |
| 著者 ローマ字 |
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| 著者 ローマ字 |
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Tanaka, Tatsuhide |
| 著者 ローマ字 |
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Bando, Yoshio |
| 著者 ローマ字 |
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| 著者 ローマ字 |
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Yoshida, Shigetaka |
| 書誌情報 |
Neuroscience
巻 236,
p. 1-11,
発行日 2013-04-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0306-4522 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.neuroscience.2012.12.073 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://www.sciencedirect.com/science/article/pii/S0306452213000389 | http://www.sciencedirect.com/science/article/pii/S0306452213000389 |
| 識別番号 その他 |
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内容記述タイプ |
Other |
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内容記述 |
PMID:23376368 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Oligodendrocytes are important for not only nerve conduction but also central nervous system (CNS) development and neuronal survival in a variety of conditions. Kallikrein-related peptidase 6 (KLK6) is expressed in oligodendrocytes in the CNS and its expression is changed in several physiological and pathological conditions, especially following spinal cord injury (SCI) and experimental autoimmune encephalomyelitis. In this study, we investigated the functions of KLK6 in oligodendrocyte lineage cell development and the production of myelin proteins using KLK6-deficient (KLK6(-/-)) mice. KLK6(-/-) mice were born without apparent defects and lived as long as wild-type (WT) mice. There was no significant difference in the numbers of oligodendrocyte precursor cells and mature oligodendrocytes in the adult naive spinal cord between WT and KLK6(-/-) mice. However, there were fewer mature oligodendrocytes in the KLK6(-/-) spinal cord than in the WT spinal cord at postnatal day 7 (P7). Expression of myelin basic protein (MBP) and oligodendrocyte-specific protein/claudin-11, major myelin proteins, was also decreased in the KLK6(-/-) spinal cord compared with the WT spinal cord at P7-21. Moreover, after SCI, the amount of MBP in the damaged spinal cords of KLK6(-/-) mice was significantly less than that in the damaged spinal cords of WT mice. These results indicate that KLK6 plays a functional role in oligodendrocyte development and the expression of myelin proteins. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
CC-BY-NC-ND |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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23376368 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1132 |
6363.pdf (998.3 kB)
