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Nerve injury induces the expression of syndecan-1 heparan sulfate proteoglycan in peripheral motor neurons
https://asahikawa-med.repo.nii.ac.jp/records/5378
https://asahikawa-med.repo.nii.ac.jp/records/5378199d610f-d856-460c-8ead-c8790f747a63
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6360.pdf (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||
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| 公開日 | 2016-03-15 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Nerve injury induces the expression of syndecan-1 heparan sulfate proteoglycan in peripheral motor neurons | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| キーワード | Syndecan | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| キーワード | Heparan sulfate proteoglycan | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| キーワード | Nerve injury | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| キーワード | Nerve regeneration | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 著者 |
村上, 公一
× 村上, 公一
× 吉田, 成孝
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| 著者 ローマ字 | ||||||||||||||
| Murakami, Koichi | ||||||||||||||
| 著者 ローマ字 | ||||||||||||||
| Yoshida, Shigetaka | ||||||||||||||
| 書誌情報 |
Neuroscience Letters 巻 527, 号 1, p. 28-33, 発行日 2012-10-01 |
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| ISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 0304-3940 | |||||||||||||
| リンクURL | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | http://www.sciencedirect.com/science/article/pii/S0304394012011214 | http://www.sciencedirect.com/science/article/pii/S0304394012011214 | |||||||||||||
| 識別番号 その他 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | PMID:22944346 | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Heparan sulfate proteoglycans play important roles in embryogenesis, including the development of the central nervous system. However, their function in nerve regeneration is not yet understood. We previously reported that nerve injury induces the expression of heparan sulfate glycosaminoglycans and syndecan-1, a heparan sulfate proteoglycan, in injured hypoglossal motor neurons. In this study, we examined the expression of syndecan family members, including syndecan-1, in injured hypoglossal motor neurons after hypoglossal nerve axotomy. We could not detect any changes in expression after axotomy, except for syndecan-1. The expression of syndecan-1 was markedly increased on post-operative day 7. Syndecan-1 was localized not only in the cell bodies of hypoglossal motor neurons, but also in the injured hypoglossal nerve, and it accumulated in the terminals of regenerating fibers. Similarly, facial nerve axotomy and vagus nerve axotomy induced the expression of syndecan-1 in the facial nucleus, dorsal nucleus of vagus and ambiguous nucleus, respectively. However, sciatic nerve axotomy induced very little syndecan-1 expression in injured spinal motor neurons. These results suggest that syndecan-1 may have a crucial role in the survival of injured motor neurons and in nerve regeneration after injury. Our observations also reveal the diversity of peripheral motor neurons. | |||||||||||||
| 注記 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 注記 | CC-BY-NC-ND | |||||||||||||
| 資源タイプ | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 資源タイプ | text | |||||||||||||
| 著者版フラグ | ||||||||||||||
| 出版タイプ | AM | |||||||||||||
| フォーマット | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | application/pdf | |||||||||||||
| ID(XooNIps) | ||||||||||||||
| 22944346 | ||||||||||||||
| 閲覧数(XooNIps) | ||||||||||||||
| ダウンロード数(XooNIps) | ||||||||||||||
| 382 | ||||||||||||||
