| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2016-02-08 |
| タイトル |
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タイトル |
An injured tissue affects the opposite intact peritoneum during postoperative adhesion formation |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
鈴木, 達也
河野, 透
暮地本, 宙己
平, 義樹
渡辺, 剛
古川, 博之
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| 著者 ローマ字 |
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Suzuki, Tatsuya |
| 著者 ローマ字 |
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Kono, Toru |
| 著者 ローマ字 |
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Bochimoto, Hiroki |
| 著者 ローマ字 |
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Hira, Yoshiki |
| 著者 ローマ字 |
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Watanabe, Tsuyoshi |
| 著者 ローマ字 |
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Furukawa, Hiroyuki |
| 書誌情報 |
Scientific Reports
巻 5,
p. 1-11,
発行日 2015-01-01
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| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1038/srep07668 |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
http://www.nature.com/articles/srep07668 | http://www.nature.com/articles/srep07668 |
| 識別番号 その他 |
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内容記述タイプ |
Other |
|
内容記述 |
PMID:25566876 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The pathophysiology of adhesion formation needs to be clarified to reduce the adhesion-related morbidity. The epithelial characteristics of the peritoneum suggest a protective role against adhesion formation, yet how the peritoneum is involved in adhesion formation is not well characterized. We microscopically observed an experimental model of adhesion formation to investigate the effects of an injured tissue on the opposite intact peritoneum. Adhesions were induced between injured and intact hepatic lobes, and the intact peritoneum opposite to the injured tissue was examined for 8 days. The opposite intact peritoneum was denuded of mesothelial cells for 6 hours, and the remnant mesothelial cells changed morphologically for 24 hours. The detachment of mesothelial cells allowed fibrin to attach to the basement membrane of the opposite peritoneum, connecting the two lobes. Moreover, macrophages and myofibroblasts accumulated between the two lobes, and angiogenesis occurred from the opposite intact lobe to the injured lobe. These observations indicate that an injured tissue deprives the opposite intact peritoneum of its epithelial structure and causes fibrous adhesions to the opposite intact tissue. This study implies a possible role of mesothelial cells for barrier function against adhesion formation, that is, keeping mesothelial cells intact might lead to its prophylaxis. |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
Creative Commons Attribution 4.0 International License. |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
VoR |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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25566876 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1056 |
6343.pdf (5.6 MB)
