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Improved prefrontal activity in AD/HD children treated with atomoxetine: a NIRS study.
https://asahikawa-med.repo.nii.ac.jp/records/5363
https://asahikawa-med.repo.nii.ac.jp/records/5363cb954da3-65f2-41e8-9360-465e794449af
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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公開日 | 2015-05-27 | |||||
タイトル | ||||||
タイトル | Improved prefrontal activity in AD/HD children treated with atomoxetine: a NIRS study. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Atomoxetine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Attention deficit/hyperactivity disorder | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Continuous performance task | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Near-infrared spectroscopy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prefrontal cortex | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
荒木, 章子
× 荒木, 章子× 池上, 将永× 岡山, 亜貴恵× 松本, 直也× 高橋, 悟× 東, 寛× 高橋, 雅治 |
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著者 ローマ字 | ||||||
値 | Araki, Akiko | |||||
著者 ローマ字 | ||||||
値 | Ikegami, Masanaga | |||||
著者 ローマ字 | ||||||
値 | Okayama, Akie | |||||
著者 ローマ字 | ||||||
値 | Matsumoto, Naoya | |||||
著者 ローマ字 | ||||||
値 | Takahashi, Satoru | |||||
著者 ローマ字 | ||||||
値 | Azuma, Hiroshi | |||||
著者 ローマ字 | ||||||
値 | Takahashi, Masaharu | |||||
書誌情報 |
Brain and Development 巻 37, 号 1, p. 76-87, 発行日 2015-01-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0387-7604 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.braindev.2014.03.011 | |||||
識別番号 その他 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PMID:24767548 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND/AIMS: \nAtomoxetine (ATX), a selective norepinephrine reuptake inhibitor, is the first approved non-stimulant drug for treatment of attention deficit/hyperactivity disorder (AD/HD). The present study examined the effects of long-term treatment with ATX on prefrontal hemodynamic activity in AD/HD children during a continuous performance task (CPT) using near-infrared spectroscopy (NIRS). METHODS: \nPrefrontal hemodynamic activity was measured in 12 children with AD/HD during experimental sessions conducted before and 6 months or more after starting ATX treatment. The average maintenance dose of ATX was 1.6 mg/kg/day. Fourteen age-matched typically developing children participated as a control group. RESULTS: \nIn the control group, the CPT induced a significant increase in oxygenated hemoglobin (oxy-Hb) concentration in the bilateral dorsolateral prefrontal cortex (DLPFC). In the AD/HD group in the pre-ATX condition, the CPT did not induce a significant increase in oxy-Hb concentration in any of the NIRS channels, but induced a significant decrease in oxy-Hb concentration in the left ventrolateral prefrontal cortex (VLPFC). In the AD/HD group in the post-ATX condition, significant activation was observed in the right DLPFC and the decrease in oxy-Hb concentration in the left VLPFC disappeared. CONCLUSIONS: \nThese results suggest that long-term treatment with ATX improved prefrontal hemodynamic activity in AD/HD children, and NIRS may be useful for assessment of the prefrontal hemodynamic response to ATX treatment. |
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注記 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 著者最終原稿版 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
ID(XooNIps) | ||||||
値 | 24767548 | |||||
閲覧数(XooNIps) | ||||||
値 | 719 | |||||
ダウンロード数(XooNIps) | ||||||
値 | 730 |