| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2015-10-22 |
| タイトル |
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タイトル |
A Quantitative Evaluation of Hepatic Uptake on I-131 Whole-Body Scintigraphy for Postablative Therapy of Thyroid Carcinoma. |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
中山, 理寛
沖崎, 貴琢
坂口, 美喜
石戸谷, 俊太
宇野, 貴寛
佐藤, 順一
高橋, 康二
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| 著者 ローマ字 |
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Nakayama, Michihiro |
| 著者 ローマ字 |
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Okizaki, Atsutaka |
| 著者 ローマ字 |
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Sakaguchi, Miki |
| 著者 ローマ字 |
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Ishitoya, Shunta |
| 著者 ローマ字 |
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Uno, Takahiro |
| 著者 ローマ字 |
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Sato, Junichi |
| 著者 ローマ字 |
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Takahashi, Koji |
| 書誌情報 |
Medicine (Baltimore).
巻 94,
号 28,
発行日 2015-07-01
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| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1097/MD.0000000000001191. |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://journals.lww.com/md-journal/pages/articleviewer.aspx?year=2015&issue=07030&article=00036&type=abstract | http://journals.lww.com/md-journal/pages/articleviewer.aspx?year=2015&issue=07030&article=00036&type=abstract |
| 識別番号 その他 |
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内容記述タイプ |
Other |
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内容記述 |
PMID:26181567 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
This study aimed to determine clinical association between quantitative hepatic uptake on postablative whole-body scan (WBS) with differentiated thyroid cancer (DTC) prognosis. We analyzed 541 scans of 216 DTC patients who were divided into 3 groups based on radioactive iodine (I-131) WBS uptake and clinical follow-up: group 1 (completion of ablation), group 2 (abnormal uptake in the cervical region), and group 3 (abnormal uptake with distant metastases). For each group, we calculated the ratio of I-131 WBS hepatic uptake (H) to cranial uptake as background (B); this ratio was defined as H/B. Furthermore, we made a distinction between group 1, as having completed radioactive iodine therapy (RIT) (CR), and group 2 and 3, as requiring subsequent RIT (RR). The average H/B scores were 1.34 (median, 1.36; range 1.00-2.1) for group 1; 1.89 (median, 1.75; range 1.41-4.20) for group 2; and 2.09 (median, 1.90; range 1.50-4.32) for group 3. Bonferroni multiple comparisons revealed significant differences in H/B among these groups. The H/B of group 1 was significantly smaller than that of other 2 groups (P < 0.0001). The precise cutoff value of H/B for therapeutic effect was ≤1.5. Moreover, 159 of 160 scans in the CR and 375 of 381 patients in the RR were correctly diagnosed using this cutoff value in the final outcome of RIT, yielding a sensitivity, specificity, positive predictive value, and negative predictive value of 99.4%, 98.4%, 99.7%, and 96.3%, respectively. Increased hepatic uptake of I-131 on WBS may predict disease-related progression. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
CC BY 4.0
オープンアクセス論文 |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
VoR |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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26181567 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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985 |
6221.pdf (304.6 kB)
