| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2015-10-21 |
| タイトル |
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タイトル |
Differential reactivation of fetal/neonatal genes in mouse liver tumors induced in cirrhotic and non-cirrhotic conditions. |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
Hepatocellular carcinoma |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
insulin-like growth factor 2 |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
liver cirrhosis |
| キーワード |
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|
主題Scheme |
Other |
|
キーワード |
mRNA expression |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
trefoil factor 3 |
| 資源タイプ |
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|
資源タイプ |
journal article |
| 著者 |
陳, 錫
山本, 雅大
藤井, 清永
長濱, 康晴
大塩, 貴子
辛, 氷
岡田, 洋子
古川, 博之
西川, 祐司
|
| 著者 ローマ字 |
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Chen, Xi |
| 著者 ローマ字 |
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Yamamoto, masahiro |
| 著者 ローマ字 |
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Fujii, Kiyonaga |
| 著者 ローマ字 |
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|
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Nagahama, Yasuharu |
| 著者 ローマ字 |
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Ooshio, Takako |
| 著者 ローマ字 |
|
|
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Xin, Bing |
| 著者 ローマ字 |
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Okada, Yoko |
| 著者 ローマ字 |
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Furukawa, Hiroyuki |
| 著者 ローマ字 |
|
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Nishikawa, Yuji |
| 書誌情報 |
Cancer science
巻 106,
号 8,
p. 972-981,
発行日 2015-08-01
|
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1347-9032 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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|
関連識別子 |
10.1111/cas.12700 |
| 識別番号 その他 |
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内容記述タイプ |
Other |
|
内容記述 |
PMID:26011625 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Hepatocellular carcinoma develops in either chronically injured or seemingly intact livers. To explore the tumorigenic mechanisms underlying these different conditions, we compared the mRNA expression profiles of mouse hepatocellular tumors induced by the repeated injection of CCl4 or a single diethylnitrosamine (DEN) injection using a cDNA microarray. We identified tumor-associated genes that were expressed differentially in the cirrhotic CCl4 model (H19, Igf2, Cbr3, and Krt20) and the non-cirrhotic DEN model (Tff3, Akr1c18, Gpc3, Afp, and Abcd2) as well as genes that were expressed comparably in both models (Ly6d, Slpi, Spink3, Scd2, and Cpe). The levels and patterns of mRNA expression of these genes were validated by quantitative RT-PCR analyses. Most of these genes were highly expressed in mouse livers during the fetal/neonatal periods. We also examined the mRNA expression of these genes in mouse tumors induced by thioacetamide, another cirrhotic inducer, and those that developed spontaneously in non-cirrhotic livers and found that they shared a similar expression profile as that observed in CCl4 -induced and DEN-induced tumors, respectively. There was a close relationship between the expression levels of Igf2 and H19 mRNA, which were activated in the cirrhotic models. Our results show that mouse liver tumors reactivate fetal/neonatal genes, some of which are specific to cirrhotic or non-cirrhotic modes of pathogenesis. |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
オープンアクセス |
| 資源タイプ |
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|
内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
VoR |
| フォーマット |
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| ID(XooNIps) |
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26011625 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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|
943 |
6220.pdf (1.3 MB)
