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Developmental potential of 2n/3n mixoploid mouse embryos produced by fusion of individual second polar bodies and blastomeres of 2-cell embryos.
https://asahikawa-med.repo.nii.ac.jp/records/5264
https://asahikawa-med.repo.nii.ac.jp/records/52647be2cc0a-7f72-403d-b07a-a51dffdb5d2e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6197.pdf (380.2 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||
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| 公開日 | 2015-09-08 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Developmental potential of 2n/3n mixoploid mouse embryos produced by fusion of individual second polar bodies and blastomeres of 2-cell embryos. | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| キーワード | chromosome | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| キーワード | embryo manipulation | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| キーワード | mosaicism | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| キーワード | zygote | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 著者 |
日野, 敏昭
× 日野, 敏昭
× 立野, 裕幸
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| 著者 ローマ字 | ||||||||||||||
| Hino, Toshiaki | ||||||||||||||
| 著者 ローマ字 | ||||||||||||||
| Tateno, Hiroyuki | ||||||||||||||
| 書誌情報 |
Reproduction, Fertility and Development 号 7, 発行日 2015-07-01 |
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| ISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 1031-3613 | |||||||||||||
| DOI | ||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | 10.1071/RD15081. | |||||||||||||
| リンクURL | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | http://www.publish.csiro.au/index.cfm?paper=RD15081 | http://www.publish.csiro.au/index.cfm?paper=RD15081 | |||||||||||||
| 識別番号 その他 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | PMID:26151553 | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Using 2n/3n mixoploid mouse embryos produced by fusion of individual second polar bodies (PB2s) with individual blastomeres of 2-cell embryos, the dynamics of PB2 nuclei in the host blastomeres during mitosis were examined and the fate of the 3n cell line in the mixoploid embryos was followed. Most of the PB2 nuclei were synchronised with the cell cycle of the host blastomeres and all chromosomes were incorporated into a single mitotic spindle. The majority of the mixoploid embryos developed to blastocysts with 3n cells. In conceptuses at Day 11.5 and Day 18.5 of gestation, 3n cells were recognised in both of the embryonic/fetal and placental tissues. When green fluorescent protein (GFP)-transgenic mice were used as a donor of PB2, GFP-positive 3n cells were found in more than 40% of morulae and blastocysts, indicating that the PB2 genome can be reactivated during the pre-implantation stage. GFP-positive 3n cells were non-randomly allocated in trophectoderm in blastocysts. These findings may explain the production mechanism of 2n/3n mixoploid human embryos, that is, a PB2 is incorporated into one daughter blastomere during the early cleavage period. | |||||||||||||
| 資源タイプ | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 資源タイプ | text | |||||||||||||
| 著者版フラグ | ||||||||||||||
| 出版タイプ | AM | |||||||||||||
| フォーマット | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | application/pdf | |||||||||||||
| ID(XooNIps) | ||||||||||||||
| 26151553 | ||||||||||||||
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| ダウンロード数(XooNIps) | ||||||||||||||
| 481 | ||||||||||||||
