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Photodynamic diagnosis of pleural malignant lesions with a combination of 5-aminolevulinic acid and intrinsic fluorescence observation systems.
https://asahikawa-med.repo.nii.ac.jp/records/5249
https://asahikawa-med.repo.nii.ac.jp/records/5249d794cafd-4ea8-4458-8fa4-7fa8baf64255
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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公開日 | 2015-07-16 | |||||
タイトル | ||||||
タイトル | Photodynamic diagnosis of pleural malignant lesions with a combination of 5-aminolevulinic acid and intrinsic fluorescence observation systems. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 5-aminolevulinic acid (5ALA) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Photodynamic diagnosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Autofluorescence imaging system | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
北田, 正博
× 北田, 正博× 大崎, 能伸× 松田, 佳也× 林, 諭史× 石橋, 佳 |
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著者 ローマ字 | ||||||
値 | Kitada, Masahiro | |||||
著者 ローマ字 | ||||||
値 | Ohsaki, Yoshinobu | |||||
著者 ローマ字 | ||||||
値 | Matsuda, Yoshinari | |||||
著者 ローマ字 | ||||||
値 | Hayashi, Satoshi | |||||
著者 ローマ字 | ||||||
値 | Ishibashi, Kei | |||||
書誌情報 |
BMC cancer 巻 15, p. 174, 発行日 2015-03-01 |
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DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1186/s12885-015-1194-0 | |||||
識別番号 その他 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PMID:25886532 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Abstract BACKGROUND: \nWe have developed a new diagnostic method using the photosensitizer 5-aminolevulinic acid (5ALA) for diagnosing intrathoracic malignant lesions. When ingested exogenously, 5ALA is metabolized to a heme precursor, protoporphyrin IX, which stays in malignant cells and emits red to pink luminescence of about 630 nm. METHODS: \nWe enrolled 40 patients who underwent respiratory surgery and consented to participate in this study. Twenty-eight patients had primary lung cancer, 8 metastatic lung tumors, 2 malignant pleural tumors, and 2 benign tumors. Localization of malignant lesions was attempted by observing such lesions with an autofluorescence imaging system and by comparing the color tone of the autofluorescence between malignant lesions and normal tissues after oral administration of 5ALA. Malignant lesions on the pleural surface emitted pink autofluorescence in contrast to the green autofluorescence of the surrounding normal tissues. RESULTS: \nWhen 28 patients with primary lung cancer were examined according to the degree of pleural infiltration (pl), red fluorescence was confirmed in 10 of 10 patients (100%) with p11-p13 and 5 of 18 patients (27.7%) with p10. The latter 5 patients had been diagnosed with PL1 preoperatively or intraoperatively. CONCLUSION: \nThis system achieved accurate localization of malignant lesions, suggesting that it may also be applicable to photodynamic therapy. |
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注記 | ||||||
内容記述タイプ | Other | |||||
内容記述 | オープンアクセス | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
ID(XooNIps) | ||||||
値 | 25886532 | |||||
閲覧数(XooNIps) | ||||||
値 | 606 | |||||
ダウンロード数(XooNIps) | ||||||
値 | 1133 |