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Force-inhibiting effect of Ser/Thr protein phosphatase 2A inhibitors on bovine ciliary muscle.
https://asahikawa-med.repo.nii.ac.jp/records/5245
https://asahikawa-med.repo.nii.ac.jp/records/524528767b1b-8438-4f5b-9212-c860cf0b8cfb
名前 / ファイル | ライセンス | アクション |
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6164.pdf (501.3 kB)
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Item type | 学位論文 / Thesis or Dissertation_02(1) | |||||
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公開日 | 2015-07-15 | |||||
タイトル | ||||||
タイトル | Force-inhibiting effect of Ser/Thr protein phosphatase 2A inhibitors on bovine ciliary muscle. | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
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資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
石田, 美織
× 石田, 美織 |
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著者 ローマ字 | ||||||
値 | Ishida, Miori | |||||
書誌情報 |
Journal of smooth muscle research 巻 51, p. 10-21, 発行日 2015-01-01 |
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DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1540/jsmr.51.10. | |||||
学位授与番号 | ||||||
学位授与番号 | 甲482 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 10107 | |||||
学位授与機関名 | 旭川医科大学 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Ciliary muscle is a smooth muscle characterized by a rapid response to muscarinic receptor stimulation and sustained contraction. Although it is evident that these contractions are Ca(2+)-dependent, detailed molecular mechanisms are still unknown. In order to elucidate the role of Ser/Thr protein phosphatase 2A (PP2A) in ciliary muscle contraction, we examined the effects of okadaic acid and other PP2A inhibitors on contractions induced by carbachol (CCh) and ionomycin in bovine ciliary muscle strips (BCM). Okadaic acid inhibited ionomycin-induced contraction, while it did not cause significant changes in CCh-induced contraction. Fostriecin showed similar inhibitory effects on the contraction of BCM. On the other hand, rubratoxin A inhibited both ionomycin- and CCh-induced contractions. These results indicated that PP2A was involved at least in ionomycin-induced Ca(2+)-dependent contraction, and that BCM had a unique regulatory mechanism in CCh-induced contraction. | |||||
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内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
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出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
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内容記述タイプ | Other | |||||
内容記述 | application/pdf |