| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2015-07-08 |
| タイトル |
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タイトル |
Successful curative resection of gallbladder cancer following S‑1 chemotherapy: A case report and review of the literature |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
S-1 |
| キーワード |
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|
主題Scheme |
Other |
|
キーワード |
gallbladder cancer |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
gene expression |
| 資源タイプ |
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|
資源タイプ |
journal article |
| 著者 |
永生, 高広
内田, 浩一郎
谷口, 雅彦
太田, 雄
渡邉, 賢二
今井, 浩二
唐崎, 秀則
千葉, 篤
及川, 賢輔
三代川, 斉之
古川, 博之
|
| 著者 ローマ字 |
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Einama, Takahiro |
| 著者 ローマ字 |
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Uchida, Koichiro |
| 著者 ローマ字 |
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Taniguchi, masahiko |
| 著者 ローマ字 |
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Ota, Yu |
| 著者 ローマ字 |
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Watanabe, Kenji |
| 著者 ローマ字 |
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Imai, koji |
| 著者 ローマ字 |
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Karasaki, Hidenori |
| 著者 ローマ字 |
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Chiba, Atsushi |
| 著者 ローマ字 |
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Oikawa, Kensuke |
| 著者 ローマ字 |
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Miyokawa, Naoyuki |
| 著者 ローマ字 |
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Furukawa, Hiroyuki |
| 書誌情報 |
Oncology letters.
巻 8,
号 6,
p. 2443-2447,
発行日 2014-12-01
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| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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|
関連識別子 |
10.3892/ol.2014.2565 |
| 識別番号 その他 |
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内容記述タイプ |
Other |
|
内容記述 |
PMID:25360167 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
The symptoms of gallbladder cancer (GBC) are vague and non-specific. Therefore, GBC is often detected at an advanced or metastatic stage. The most effective treatment for GBC is surgical resection, however the majority of GBC cases are unresectable at the time of diagnosis. Therefore, numerous GBC patients undergo chemotherapy. This study reports the case of a 60-year-old female with GBC who underwent successful surgical curative resection following a single dose of the chemotherapeutic agent, S-1, twice daily for 4 weeks followed by a 14-day rest period for 36 months. S-1 is a novel orally administered drug composed of a combination of the 5-fluorouracil (5-FU) prodrug, tegafur, 5-chloro-2,4-dihydroxypyridine (CDHP) and oteracil potassium in a 1:0.4:1 molar concentration ratio. The focus of the present study was the candidate factors that affect the therapeutic efficacy of S-1-based chemotherapy. In particular, the gene expression involved in the S-1 metabolic pathway was investigated by assessing the intratumoral dihydropyrimidine dehydrogenase (DPD), thymidylate synthase (TS) and orotate phosphoribosyltransferase gene expression. The surgical specimen exhibited high intratumoral DPD gene expression levels compared with those observed in previously reported non S-1 responsive cases of biliary tract cancer. Due to the results obtained in the current study, we hypothesize that CDHP enhanced the antitumor efficacy of 5-FU by inhibiting the excess DPD protein produced by the tumor. |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
オープンアクセス誌 |
| 資源タイプ |
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|
内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
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|
出版タイプ |
VoR |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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25360167 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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|
875 |
6158.pdf (885.6 kB)
