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Association between Microalbuminuria Predicting In-Stent Restenosis after Myocardial Infarction and Cellular Senescence of Endothelial Progenitor Cells.
https://asahikawa-med.repo.nii.ac.jp/records/5237
https://asahikawa-med.repo.nii.ac.jp/records/523754f095d3-14d1-4ff2-8095-0f7126854ced
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6145.pdf (662.3 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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| 公開日 | 2015-06-10 | |||||
| タイトル | ||||||
| タイトル | Association between Microalbuminuria Predicting In-Stent Restenosis after Myocardial Infarction and Cellular Senescence of Endothelial Progenitor Cells. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
太田, 久宣
× 太田, 久宣× 竹原, 有史× 青沼, 達也× 鹿原, 真樹× 松木, 孝樹× 山内, 敦司× 竹内, 利治× 川辺, 淳一× 長谷部, 直幸 |
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| 著者 ローマ字 | ||||||
| 値 | Ota, Hisanobu | |||||
| 著者 ローマ字 | ||||||
| 値 | Takehara, Naofumi | |||||
| 著者 ローマ字 | ||||||
| 値 | Aonuma, Tatsuya | |||||
| 著者 ローマ字 | ||||||
| 値 | Kabara, Maki | |||||
| 著者 ローマ字 | ||||||
| 値 | Matsuki, Motoki | |||||
| 著者 ローマ字 | ||||||
| 値 | Yamauchi, Atsushi | |||||
| 著者 ローマ字 | ||||||
| 値 | Takeuchi, Toshiharu | |||||
| 著者 ローマ字 | ||||||
| 値 | Kawabe, Jun-ichi | |||||
| 著者 ローマ字 | ||||||
| 値 | Hasebe, Naoyuki | |||||
| 書誌情報 |
PLoS One. 巻 10, 号 4, 発行日 2015-04-01 |
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| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1371/journal.pone.0123733 | |||||
| 識別番号 その他 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PMID:25874702 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | OBJECTIVE: \nRelationship between microalbuminuria and worse outcome of coronary artery disease patients is discussed, but its underlying pathophysiological mechanism remains unclear. We investigated the role of microalbuminuria to the function of endothelial progenitor cells (EPCs), that might affect to outcome of acute myocardial infarction (AMI) patients. METHODS: \nForty-five AMI patients were divided into two groups according to their urinary albumin excretion: normal (n = 24) and microalbuminuria (>30 mg/day, n = 21). At day-2 and day-7 after AMI onset, circulating-EPCs (CD34+Flk1+) were quantified by flow cytometry. The number of lectin-acLDL-positive cultured-EPCs immobilized on fibronectin was determined. To assess the cellular senescence of cultured-EPCs, the expression level of sirtuin-1 mRNA and the number of SA-β-gal positive cell were evaluated. Angiographic late in-stent loss after percutaneous coronary intervention (PCI) was evaluated at a six-month follow-up. RESULTS: \nNo significant differences in coronary risk and the extent of myocardial damage were observed between the two groups. Late in-stent loss at the six-month follow-up was significantly higher in the microalbuminuria group (normal : microalbuminuria = 0.76±0.34 : 1.18±0.57 mm, p=0.021). The number of circulating-EPCs was significantly increased in microalbuminuria group at day-7, however, improved adhesion of EPCs was observed in normal group but not in microalbuminuria group from baseline to day-7 (+3.1±8.3 : -1.3±4.4 %: p<0.05). On the other hand, in microalbuminuria group at day-7, the level of sirtuin-1 mRNA expression of cultured-EPCs was significantly decreased (7.1±8.9 : 2.5±3.7 fold, p<0.05), which was based on the negative correlation between the level of sirtuin-1 mRNA expression and the extent of microalbuminuria. The ratio of SA-β-gal-positive cells in microalbuminuria group was increased compared to that of normal group. CONCLUSIONS: \nMicroalbuminuria in AMI patients is closely associated with functional disorder of EPCs via cellular senescence, that predicts the aggravation of coronary remodeling after PCI. |
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| 注記 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | オープンアクセス | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| ID(XooNIps) | ||||||
| 値 | 25874702 | |||||
| 閲覧数(XooNIps) | ||||||
| 値 | 703 | |||||
| ダウンロード数(XooNIps) | ||||||
| 値 | 1057 | |||||
