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Non-Vitamin K Antagonist Oral Anticoagulants Do Not Increase Cerebral Microbleeds
https://asahikawa-med.repo.nii.ac.jp/records/5235
https://asahikawa-med.repo.nii.ac.jp/records/523558238098-3e3f-4a16-92a2-4fe8992fcf09
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6142.pdf (132.8 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-06-09 | |||||
| タイトル | ||||||
| タイトル | Non-Vitamin K Antagonist Oral Anticoagulants Do Not Increase Cerebral Microbleeds | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NOAC | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | warfarin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cerebral microbleeds | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | atrial fibrillation | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
斉藤, 司
× 斉藤, 司× 川村, 祐一郎× 佐藤, 伸之× 鹿野, 耕平× 高橋, 佳恵× 浅野目, 明日香× 澤田, 潤× 片山, 隆行× 長谷部, 直幸 |
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| 著者 ローマ字 | ||||||
| 値 | Saito, Tsukasa | |||||
| 著者 ローマ字 | ||||||
| 値 | Kawamura, Yuichiro | |||||
| 著者 ローマ字 | ||||||
| 値 | Sato, Nobuyuki | |||||
| 著者 ローマ字 | ||||||
| 値 | Kano, Kohei | |||||
| 著者 ローマ字 | ||||||
| 値 | Takahashi, Kae | |||||
| 著者 ローマ字 | ||||||
| 値 | Asanome, Asuka | |||||
| 著者 ローマ字 | ||||||
| 値 | Sawada, Jun | |||||
| 著者 ローマ字 | ||||||
| 値 | Katayama, takayuki | |||||
| 著者 ローマ字 | ||||||
| 値 | Hasebe, Naoyuki | |||||
| 書誌情報 |
Journal of Stroke and Cerebrovascular Diseases 巻 24, 号 6, p. 1373-1377, 発行日 2015-06-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1052-3057 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.jstrokecerebrovasdis.2015.02.018. | |||||
| 識別番号 その他 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PMID:25847305 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | BACKGROUND: \nAtrial fibrillation (AF) is a cardiac arrhythmia that frequently induces ischemic strokes. Nowadays, non-vitamin K antagonist oral anticoagulants (NOACs) have come into widespread use for cardiogenic embolism prevention in place of warfarin. Recently, cerebral microbleeds (CMBs) have been noticed for their potential implication in cerebral small vessel disease. We hypothesized that NOACs do not have an unfavorable influence over cerebral small vessels and investigated whether NOACs increase CMBs in AF patients in a prospective manner. METHODS: \nWe performed baseline magnetic resonance imaging (MRI) examinations on the 69 enrolled AF patients and re-examined second round of MRI 1 year later. The enrolled patients continued the same anticoagulation therapy during the meantime. RESULTS: \nCMBs did not develop in the 23 patients with NOACs for 1 year. Nine patients with antiplatelets also did not develop CMBs. On the other hand, 3 of 21 patients continued on warfarin and 3 of 9 with warfarin and antiplatelets had CMBs. When divided into 2 groups according to whether the CMBs developed, significant differences in the incidence of using NOACs were observed between the 2 groups (P = .02). A multivariate regression analysis showed that warfarin was independently related to the new development of CMBs (hazard ratio, 10.75; 95% confidence interval, 1.22-94.99; P = .03). CONCLUSIONS: \nThis is the first report to clarify that NOACs do not increase CMBs in AF patients longitudinally in 1 year. Further consideration will be continued with a much longer follow-up in large samples. |
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| 注記 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | オープンアクセス CC-BY-NC-ND |
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| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| ID(XooNIps) | ||||||
| 値 | 25847305 | |||||
| 閲覧数(XooNIps) | ||||||
| 値 | 749 | |||||
| ダウンロード数(XooNIps) | ||||||
| 値 | 1358 | |||||
