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Initial reduction of oxidative stress by angiotensin receptor blocker contributes long term outcomes after percutaneous coronary intervention.
https://asahikawa-med.repo.nii.ac.jp/records/5227
https://asahikawa-med.repo.nii.ac.jp/records/5227a3f97b3d-fa67-4fd7-97e1-d6b84d934d7a
名前 / ファイル | ライセンス | アクション |
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6129.pdf (721.9 kB)
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Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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公開日 | 2015-05-26 | |||||
タイトル | ||||||
タイトル | Initial reduction of oxidative stress by angiotensin receptor blocker contributes long term outcomes after percutaneous coronary intervention. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | Angiotensin receptor blocker | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | PCI | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | ROS | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | mononuclear cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
キーワード | oxidative stress | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
野呂, 忠孝
× 野呂, 忠孝× 竹原, 有史× 住友, 和弘× 竹内, 利治× 石井, 良直× 加藤, 淳一× 川辺, 淳一× 長谷部, 直幸 |
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著者 ローマ字 | ||||||
Noro, Tadanori | ||||||
著者 ローマ字 | ||||||
Takehara, Naofumi | ||||||
著者 ローマ字 | ||||||
Sumitomo, Kazuhiro | ||||||
著者 ローマ字 | ||||||
Takeuchi, Toshiharu | ||||||
著者 ローマ字 | ||||||
Ishii, Yoshinao | ||||||
著者 ローマ字 | ||||||
Kato, Jun-ichi | ||||||
著者 ローマ字 | ||||||
Kawabe, Jun-ichi | ||||||
著者 ローマ字 | ||||||
Hasebe, Naoyuki | ||||||
書誌情報 |
American journal of cardiovascular disease 巻 4, 号 4, p. 159-167, 発行日 2014-12-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2160-200X | |||||
リンクURL | ||||||
内容記述タイプ | Other | |||||
内容記述 | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299694/ | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299694/ | |||||
識別番号 その他 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PMID:25628957 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND: \nIt remains unclear whether administration of ARB with reactive oxygen species (ROS) scavenging effects improves the prognosis of patients undergoing PCI. OBJECTIVES: \nThis study investigated whether the pre-intervention antioxidant effect of angiotensin receptor blocker (ARB) affects long-term outcomes in patients after successful percutaneous coronary intervention (PCI) without early adverse events. METHODS: \nFifty-two patients who underwent elective PCI were randomly assigned for treatment with or without ARB, which was administered within 48 hours before PCI. ROS levels in mononuclear cells (MNCs) and serum superoxide dismutase (SOD) activity were measured pre-PCI and 6 months post-PCI. After exclusion of unexpected early adverse events during angiographic follow-up period, the long-term outcome (major adverse cerebro-cardiovascular event; MACCE) was assessed in eligible patients. RESULTS: \nForty-three patients (non-ARB n = 22, ARB n = 21) were followed up in this study. During angiographic follow-up period, ROS formation in MNCs was significantly increased in the non-ARB group (from 29.4 [21.6-35.2] to 37.2 [30.7-45.1] arbitrary units; p = 0.031) compared to that in the ARB group. Meanwhile, SOD activity was significantly impaired in the non-ARB group alone (from 24.0 ± 17.0 to 16.3 ± 13.8%, p = 0.004). During the follow-up period (median, 63.3 months), MACCEs were observed in 6 patients. The cumulative event ratio of MACCE was significantly higher in the non-ARB group than in the ARB group (p = 0.018). CONCLUSIONS: \nConcomitant administration of ARB effectively reduced ROS production of PCI patients during angiographic follow-up period. Initial ROS inhibition following ARB administration may contribute to improvement of worse outcomes in patients who have undergone successful PCI. |
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注記 | ||||||
内容記述タイプ | Other | |||||
注記 | 出版社版 オープンアクセス |
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資源タイプ | ||||||
内容記述タイプ | Other | |||||
資源タイプ | text | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
ID(XooNIps) | ||||||
25628957 | ||||||
閲覧数(XooNIps) | ||||||
489 | ||||||
ダウンロード数(XooNIps) | ||||||
619 |