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ロクロニウム単回投与から得られた薬物動態モデル６種類の単回・持続投与時における予測性能
https://asahikawa-med.repo.nii.ac.jp/records/5171
https://asahikawa-med.repo.nii.ac.jp/records/5171f1b08b3b-42d2-4ffc-a87c-1b74d77d8ed6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6063.pdf (307.5 kB)
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| Item type | 学位論文 / Thesis or Dissertation_02(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-04-24 | |||||
| タイトル | ||||||
| タイトル | ロクロニウム単回投与から得られた薬物動態モデル６種類の単回・持続投与時における予測性能 | |||||
| 言語 | ja | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Drug delivery | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Neuromuscular blocking agent | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Pharmacokinetics | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Rocuronium | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| タイトル ローマ字 | ||||||
| その他のタイトル | Predictive performance of six compartmental pharmacokinetic models of rocuronium delivered by bolus followed by continuous infusion: Assessment of parameter sets determined using samples obtained after bolus infusion only | |||||
| 著者 |
笹川, 智貴
× 笹川, 智貴 |
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| 著者 ローマ字 | ||||||
| 値 | Sasakawa, Tomoki | |||||
| 書誌情報 |
Journal of anesthesia 巻 30, 号 4, p. 620-627, 発行日 2016-08-01 |
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| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s00540-016-2174-5 | |||||
| 識別番号 その他 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PMID:27098255 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲474 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2015-03-25 | |||||
| 学位名 | ||||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 10107 | |||||
| 学位授与機関名 | 旭川医科大学 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | PURPOSE: \nRocuronium concentration prediction using pharmacokinetic (PK) models would be useful for controlling rocuronium effects because neuromuscular monitoring throughout anesthesia can be difficult. This study assessed whether six different compartmental PK models developed from data obtained after bolus administration only could predict the measured plasma concentration (Cp) values of rocuronium delivered by bolus followed by continuous infusion. METHODS: \nRocuronium Cp values from 19 healthy subjects who received a bolus dose followed by continuous infusion in a phase III multicenter trial in Japan were used retrospectively as evaluation datasets. Six different compartmental PK models of rocuronium were used to simulate rocuronium Cp time course values, which were compared with measured Cp values. Prediction error (PE) derivatives of median absolute PE (MDAPE), median PE (MDPE), wobble, divergence absolute PE, and divergence PE were used to assess inaccuracy, bias, intra-individual variability, and time-related trends in APE and PE values. RESULTS: \nMDAPE and MDPE values were acceptable only for the Magorian and Kleijn models. The divergence PE value for the Kleijn model was lower than -10 %/h, indicating unstable prediction over time. The Szenohradszky model had the lowest divergence PE (-2.7 %/h) and wobble (5.4 %) values with negative bias (MDPE = -25.9 %). These three models were developed using the mixed-effects modeling approach. The Magorian model showed the best PE derivatives among the models assessed. CONCLUSIONS: \nA PK model developed from data obtained after single-bolus dosing can predict Cp values during bolus and continuous infusion. Thus, a mixed-effects modeling approach may be preferable in extrapolating such data. |
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| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
