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ラット肝臓の損傷された組織と正常な腹膜の間に形成される術後癒着に関する形態学的研究
https://asahikawa-med.repo.nii.ac.jp/records/5159
https://asahikawa-med.repo.nii.ac.jp/records/5159265f3dc7-c957-4430-9295-bea2839de200
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
5854.pdf (1.1 MB)
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| Item type | 学位論文 / Thesis or Dissertation_02(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2014-09-19 | |||||||||
| タイトル | ||||||||||
| タイトル | ラット肝臓の損傷された組織と正常な腹膜の間に形成される術後癒着に関する形態学的研究 | |||||||||
| 言語 | ja | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| タイトル ローマ字 | ||||||||||
| その他のタイトル | A morphological study of postoperative adhesions between injured tissue and intact peritoneum in the rat liver | |||||||||
| 著者 |
鈴木, 達也
× 鈴木, 達也
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| 著者 ローマ字 | ||||||||||
| Suzuki, Tatsuya | ||||||||||
| 書誌情報 |
Scientific Reports 巻 8, 号 5, 発行日 2015-01-01 |
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| DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1038/srep07668 | |||||||||
| 識別番号 その他 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | PMID:25566876 | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲453 | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2014-03-25 | |||||||||
| 学位名 | ||||||||||
| 学位名 | 博士（医学） | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関名 | 旭川医科大学 | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | The pathophysiology of adhesion formation needs to be clarified to reduce the adhesion-related morbidity. The epithelial characteristics of the peritoneum suggest a protective role against adhesion formation, yet how the peritoneum is involved in adhesion formation is not well characterized. We microscopically observed an experimental model of adhesion formation to investigate the effects of an injured tissue on the opposite intact peritoneum. Adhesions were induced between injured and intact hepatic lobes, and the intact peritoneum opposite to the injured tissue was examined for 8 days. The opposite intact peritoneum was denuded of mesothelial cells for 6 hours, and the remnant mesothelial cells changed morphologically for 24 hours. The detachment of mesothelial cells allowed fibrin to attach to the basement membrane of the opposite peritoneum, connecting the two lobes. Moreover, macrophages and myofibroblasts accumulated between the two lobes, and angiogenesis occurred from the opposite intact lobe to the injured lobe. These observations indicate that an injured tissue deprives the opposite intact peritoneum of its epithelial structure and causes fibrous adhesions to the opposite intact tissue. This study implies a possible role of mesothelial cells for barrier function against adhesion formation, that is, keeping mesothelial cells intact might lead to its prophylaxis. | |||||||||
| 資源タイプ | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
