WEKO3
アイテム
Hypoxia in Diabetic Kidneys
https://asahikawa-med.repo.nii.ac.jp/records/5006
https://asahikawa-med.repo.nii.ac.jp/records/50063043f5fd-a41d-4182-997b-33645437d793
名前 / ファイル | ライセンス | アクション |
---|---|---|
![]() |
|
Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2014-08-20 | |||||
タイトル | ||||||
タイトル | Hypoxia in Diabetic Kidneys | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
滝山, 由美
× 滝山, 由美× 羽田, 勝計 |
|||||
著者 ローマ字 | ||||||
値 | Takiyama, Yumi | |||||
著者 ローマ字 | ||||||
値 | Haneda, Masakazu | |||||
書誌情報 |
BioMed research international 号 2014, p. 837421, 発行日 2014-06-01 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2314-6141 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1155/2014/837421 | |||||
識別番号 その他 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PMID:25054148 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Diabetic nephropathy (DN) is now a leading cause of end-stage renal disease. In addition, DN accounts for the increased mortality in type 1 and type 2 diabetes, and then patients without DN achieve long-term survival compatible with general population. Hypoxia represents an early event in the development and progression of DN, and hypoxia-inducible factor- (HIF-) 1 mediates the metabolic responses to renal hypoxia. Diabetes induces the "fraternal twins" of hypoxia, that is, pseudohypoxia and hypoxia. The kidneys are susceptible to hyperoxia because they accept 20% of the cardiac output. Therefore, the kidneys have specific vasculature to avoid hyperoxia, that is, AV oxygen shunting. The NAD-dependent histone deacetylases (HDACs) sirtuins are seven mammalian proteins, SIRTs 1-7, which are known to modulate longevity and metabolism. Recent studies demonstrated that some isoforms of sirtuins inhibit the activation of HIF by deacetylation or noncatalyzing effects. The kidneys, which have a vascular system that protects them against hyperoxia, unfortunately experience extraordinary hypernutrition today. Then, an unexpected overload of glucose augments the oxygen consumption, which ironically results in hypoxia. This review highlights the primary role of HIF in diabetic kidneys for the metabolic adaptation to diabetes-induced hypoxia. | |||||
注記 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Publisher | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
ID(XooNIps) | ||||||
値 | 25054148 | |||||
閲覧数(XooNIps) | ||||||
値 | 689 | |||||
ダウンロード数(XooNIps) | ||||||
値 | 1426 |