| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2014-07-10 |
| タイトル |
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タイトル |
Population pharmacokinetics of olprinone in healthy male volunteers |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
phosphodiesterase III inhibitor,men,pharmacokinetic model |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
国沢, 卓之
Kasai, Hidefumi
Suda, Makoto
Yoshimura, Manabu
Sugawara, Ami
Izumi, Yuki
Iida, Takafumi
Kurosawa, Atsushi
Iwasaki, Hiroshi
|
| 著者 ローマ字 |
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Kunisawa, Takayuki |
| 著者 ローマ字 |
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Kasai, Hidefumi |
| 著者 ローマ字 |
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Suda, Makoto |
| 著者 ローマ字 |
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Yoshimura, Manabu |
| 著者 ローマ字 |
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Sugawara, Ami |
| 著者 ローマ字 |
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Izumi, Yuki |
| 著者 ローマ字 |
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Iida, Takafumi |
| 著者 ローマ字 |
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Kurosawa, Atsushi |
| 著者 ローマ字 |
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Iwasaki, Hiroshi |
| 書誌情報 |
Clinical pharmacology
号 6,
p. 43-50,
発行日 2014-03-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1179-1438 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.2147/CPAA.S50626 |
| 識別番号 その他 |
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内容記述タイプ |
Other |
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内容記述 |
PMID:24623995 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
BACKGROUND: Olprinone decreases the cardiac preload and/or afterload because of its vasodilatory effect and increases myocardial contractility by inhibiting phosphodiesterase III.
\nPURPOSE: The objective of this study was to characterize the population pharmacokinetics of olprinone after a single continuous infusion in healthy male volunteers.
\nMETHODS: We used 500 plasma concentration data points collected from nine healthy male volunteers for the study. The population pharmacokinetic analysis was performed using the nonlinear mixed effect model (NONMEM®) software.
\nRESULTS: The time course of plasma concentration of olprinone was best described using a two-compartment model. The final pharmacokinetic parameters were total clearance (7.37 mL/minute/kg), distribution volume of the central compartment (134 mL/kg), intercompartmental clearance (7.75 mL/minute/kg), and distribution volume of the peripheral compartment (275 mL/kg). The interindividual variability in the total clearance was 12.4%, and the residual error variability (exponential and additive) were 22.2% and 0.129 (standard deviation). The final pharmacokinetic model was assessed using a bootstrap method and visual predictive check.
\nCONCLUSION: We developed a population pharmacokinetic model of olprinone in healthy male adults. The bootstrap method and visual predictive check showed that this model was appropriate. Our results might be used to develop the population pharmacokinetic model in patients |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
Publisher |
| 資源タイプ |
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内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
VoR |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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24623995 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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|
871 |
5808.pdf (732.1 kB)
