| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2014-06-26 |
| タイトル |
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タイトル |
Soluble ICAM-1 secretion and its functional role as an autocrine growth factor in nasal NK/T cell lymphoma cells. |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
高原, 幹
Nagato, Toshihiro
Komabayashi, Yuhki
Yoshino, Kazumi
Ueda, Seigo
Kishibe, Kan
原渕, 保明
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| 著者 ローマ字 |
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Takahara, Miki |
| 著者 ローマ字 |
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Nagato, Toshihiro |
| 著者 ローマ字 |
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Komabayashi, Yuhki |
| 著者 ローマ字 |
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Yoshino, Kazumi |
| 著者 ローマ字 |
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Ueda, Seigo |
| 著者 ローマ字 |
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Kishibe, Kan |
| 著者 ローマ字 |
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Harabuchi, Yasuaki |
| 書誌情報 |
Experimental hematology
巻 41,
号 8,
p. 711-718,
発行日 2013-08-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0301-472X |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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|
関連識別子 |
10.1016/j.exphem.2013.03.009 |
| 識別番号 その他 |
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内容記述タイプ |
Other |
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内容記述 |
PMID:23583640 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Nasal natural killer/T-cell lymphoma (NNKTL) is associated with the Epstein-Barr virus (EBV), and has distinct histological features such as angiocentric and polymorphous lymphoreticular infiltrates that contain too many cell types, including tumour and inflammatory cells. We have previously shown that intercellular adhesion molecule (ICAM)-1 is expressed in NNKTL cells, and that soluble ICAM-1 (sICAM-1) is significantly increased in patients’ sera. However, the functional role of sICAM-1 remains unknown. In the present study, we found that EBV-positive NNKTL cell line SNK6 secreted sICAM-1 in a time-dependent manner. Moreover, exogenous sICAM-1 enhanced the growth of SNK6 cells in a dose-dependent manner. Comparatively, neutralising ICAM-1 and LFA-1 antibodies, as well as the LFA-1 blocker simvastatin, caused a dose-dependent reduction in the number of viable SNK6 cells. Double immunohistological staining of NNKTL tissues confirmed that CD56 positive lymphoma cells co-expressed LFA-1. Moreover, serum sICAM-1 levels in NNKTL patients decreased after treatment, suggesting that the levels reflected disease progression. We conclude that NNKTL cells secrete sICAM-1 that acts as an autocrine factor for lymphoma progression, and suggest that simvastatin may be a potential candidate to treat NNKTL. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
Author |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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23583640 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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877 |
5780.pdf (1.1 MB)
