| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2014-02-14 |
| タイトル |
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タイトル |
Infliximab extends the duration until the first surgery in patients with Crohn's disease. |
|
言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
坂谷, 慧
Fujiya, Mikihiro
Ito, Takahiro
Inaba, Yuhei
Ueno, Nobuhiro
Kashima, Shin
Tominaga, Motoya
Moriichi, Kentaro
Okamoto, Kotaro
Tanabe, Hiroki
Ikuta, Katsuya
Ohtake, Takaaki
Kono, Toru
Furukawa, Hiroyuki
|
| 書誌情報 |
BioMed research international
巻 2013,
p. 879491,
発行日 2013-01-01
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| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2314-6141 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1155/2013/879491 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
24371835 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background/Aims. While biological drugs are useful for relieving the disease activity and preventing abdominal surgery in patients with Crohn’s disease (CD), it is unclear whether the use of biological drugs in CD patients with no history of abdominal surgery is appropriate. We evaluated the effects of infliximab and other factors on extending the duration until the first surgery in CD patients on a long-term basis. Methods. The clinical records of 104 CD patients were retrospectively investigated. The cumulative nonoperation rate until the first surgery was examined with regard to demographic factors and treatments. Results. The 50% nonoperative interval in the 104 CD patients was 107 months. The results of a univariate analysis revealed that a female gender, the colitis type of CD, and the administration of corticosteroids, immunomodulators, or infliximab were factors estimated to improve the cumulative nonoperative rate. A multivariate analysis showed that the colitis type and administration of infliximab were independent factors associated with a prolonged interval until the first surgery in the CD patients with no history of abdominal surgery. Conclusions. This study suggests that infliximab treatment extends the duration until the first surgery in CD patients with no history of abdominal surgery. The early use of infliximab before a patient undergoes abdominal surgery is therefore appropriate. |
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言語 |
en |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
This is an open access article distributed under the Creative Commons Attribution License |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
VoR |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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24371835 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1038 |
5599.pdf (212.6 kB)
