| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2014-01-29 |
| タイトル |
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タイトル |
Models for sensory neurons of dorsal root ganglia and stress urinary incontinence |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
stress urinary incontinence |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
animal model |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
sensory neuron |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
overactive bladder |
| 資源タイプ |
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|
資源タイプ |
journal article |
| 著者 |
柿崎, 秀宏
北, 雅史
和田, 直樹
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| 著者 ローマ字 |
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Kita, Masafumi |
| 著者 ローマ字 |
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en |
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Wada, Naoki |
| 著者 ローマ字 |
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|
en |
| 書誌情報 |
Neurourology and urodynamics
巻 30,
号 5,
p. 653-657,
発行日 2011-06-01
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| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0733-2467 |
| DOI |
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関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1002/nau.21138 |
| PubMed番号 |
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|
識別子タイプ |
PMID |
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関連識別子 |
21661009 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
AIMS: To discuss (1) animal models for investigating bladder afferent pathways from the spinal cord to the brain and (2) animal models of stress urinary incontinence (SUI) with a special emphasis on functional and histopathological characteristics of each model. \nMETHODS: Literature review of spinal mechanisms of bladder afferent pathways and animal models of SUI. \nRESULTS: Electrophysiological studies in the rat using pelvic nerve stimulation and recording of evoked potentials in the periaqueductal gray (PAG) prove to be a valuable tool to examine spinal mechanisms of bladder afferent pathways. Animal models of SUI in the rat include vaginal distention as simulated birth trauma, pudendal nerve crush or transection, urethral sphincter injury by electrocauterization, transabdominal urethrolysis, periurethral botulinum-A toxin injection, and pubo-urethral ligament transection. Functional and histopathological changes in the continence mechanism after injury are different between models. \nCONCLUSIONS: Using animal models for sensory neurons, intrathecal and intravenous administration of certain drugs can be tested whether they affect the bladder afferent pathways from the spinal cord to the PAG. Animal models of SUI can serve as a tool to develop new pharmacologic therapies or periurethral injection therapies using stem cell implants. |
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言語 |
en |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
Author |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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21661009 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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557 |
5582.pdf (493.5 kB)
