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Visceral sensation and irritable bowel syndrome; with special reference to comparison with functional abdominal pain syndrome
https://asahikawa-med.repo.nii.ac.jp/records/4646
https://asahikawa-med.repo.nii.ac.jp/records/46462c0373c8-3bd5-4207-b8a8-94060ac23068
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
5452.pdf (2.3 MB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||
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| 公開日 | 2013-09-19 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Visceral sensation and irritable bowel syndrome; with special reference to comparison with functional abdominal pain syndrome | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| キーワード | barostat | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| キーワード | CRF | |||||||||||||
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| 主題Scheme | Other | |||||||||||||
| キーワード | FAPS | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| キーワード | IBS | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| キーワード | stress | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 著者 |
野津, 司
× 野津, 司
× 奥村, 利勝
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| 著者 ローマ字 | ||||||||||||||
| Okumura, Toshikatsu | ||||||||||||||
| 著者 ローマ字 | ||||||||||||||
| en | ||||||||||||||
| 書誌情報 |
Journal of gastroenterology and hepatology 巻 26, 号 Suppl.3, p. 122-127, 発行日 2011-04-01 |
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| ISSN | ||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 0815-9319 | |||||||||||||
| DOI | ||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | 10.1111/j.1440-1746.2011.06636.x | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Objective and background: Stress-induced visceral hypersensitivity may play an important role in the pathogenesis of irritable bowel syndrome (IBS) but not in functional abdominal pain syndrome (FAPS). We examined rectal sensation in those patients. Methodology: Experiment 1: Rectal thresholds of pain (PT) and maximum tolerance were assessed by barostat with ramp distention before and after repetitive rectal painful distention (RRD). Experiment 2, PT was measured in basal state and after intravenous CRF (100 μg) or vehicle, together with or without RRD. Experiment 3: Three phasic distentions at physiological range were randomly loaded. The subjects were asked to mark the visual analogue scale (VAS) in reference to subjective intensity of sensation. Results: Experiment 1: Majority of IBS patients showed rectal hypersensitivity before RRD in contrast to FAPS. All IBS patients developed hypersensitivity after RRD, however, none of the FAPS patients did. RRD significantly reduced both thresholds in IBS (n=7) but did not change in controls (n=14) and FAPS (n=6). Experiment 2: PT was not modified by RRD in placebo group (n=6), while it was significantly reduced in CRF-treated group (n=5). On the other hand, CRF (n=5) or vehicle (n=5) without RRD did not alter PT. Experiment 3: The VAS ratings were increased in IBS (n=7) but significantly decreased in FAPS (n=6) as compared to controls (n=14). Conclusions: RRD-induced rectal hypersensitivity seems to be reliable marker for IBS, and CRF may contribute to this response. FAPS patients may have hyposensitivity to non-noxious physiological distention, suggesting FAPS has different pathogenesis from IBS. | |||||||||||||
| 言語 | en | |||||||||||||
| 注記 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 注記 | Author | |||||||||||||
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| 内容記述タイプ | Other | |||||||||||||
| 資源タイプ | text | |||||||||||||
| 著者版フラグ | ||||||||||||||
| 出版タイプ | AM | |||||||||||||
| フォーマット | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | application/pdf | |||||||||||||
| ID(XooNIps) | ||||||||||||||
| 21443724 | ||||||||||||||
| 閲覧数(XooNIps) | ||||||||||||||
| ダウンロード数(XooNIps) | ||||||||||||||
| 654 | ||||||||||||||
