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Relationship Between Retinal Blood Flow and Renal Function In Patients With Type 2 Diabetes and Chronic Kidney Disease
https://asahikawa-med.repo.nii.ac.jp/records/4540
https://asahikawa-med.repo.nii.ac.jp/records/454056226544-d12b-49a5-9831-4313e8151e8d
| 名前 / ファイル | ライセンス | アクション |
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5330.pdf (1.6 MB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||
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| 公開日 | 2013-07-11 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Relationship Between Retinal Blood Flow and Renal Function In Patients With Type 2 Diabetes and Chronic Kidney Disease | |||||||||||||
| 言語 | en | |||||||||||||
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| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 著者 |
長岡, 泰司
× 長岡, 泰司
× 吉田, 晃敏
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| 著者 ローマ字 | ||||||||||||||
| Yoshida, Akitoshi | ||||||||||||||
| 著者 ローマ字 | ||||||||||||||
| en | ||||||||||||||
| 書誌情報 |
Diabetes Care 巻 36, 号 4, p. 957-961, 発行日 2013-04-01 |
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| ISSN | ||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 0149-5992 | |||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | 10.2337/dc12-0864 | |||||||||||||
| PubMed番号 | ||||||||||||||
| 識別子タイプ | PMID | |||||||||||||
| 関連識別子 | 2320424 | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | OBJECTIVE: To study the relationship between retinal microcirculation and renal function in patients with type 2 diabetes ). \nRESEARCH DESIGN AND METHODS: Using a laser Doppler velocimetry system, we obtained the retinal blood flow (RBF) values by simultaneously measuring the retinal vessel diameter and blood velocity. To determine if the RBF is affected in the presence of renal dysfunction, we also evaluated the renal function using the estimated glomerular filtration rate calculated by age and serum creatinine level. \nRESULTS: We recruited 169 eyes of 169 consecutive Japanese patients with type 2 diabetes, no or minimal diabetic retinopathy, and normo/microalbuminuria (mean age ± SD, 59.0 ± 11.1 years). We divided the patients into four groups based on the stage of chronic kidney disease (CKD) (non-CKD, n = 99; CKD stage 1, n = 22; stage 2, n = 27; stage 3, n = 21). We found significant (P = 0.035) decreases in RBF with decreased vessel diameter (P = 0.017) but no difference in blood velocity (P = 0.54) in stage 3 CKD compared with the non-CKD group. Multiple regression analysis showed that the CKD stage was significantly (P = 0.02) and independently associated with decreased RBF. \nCONCLUSIONS: Our results indicated that the vessel diameter and RBF in the retinal arterioles decrease in patients with type 2 diabetes with stage 3 CKD, suggesting that impaired renal function might be associated with decreased RBF, probably via constriction of the retinal arterioles, in early-phase diabetic retinopathy. | |||||||||||||
| 言語 | en | |||||||||||||
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| 内容記述タイプ | Other | |||||||||||||
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| 内容記述タイプ | Other | |||||||||||||
| 資源タイプ | text | |||||||||||||
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| 出版タイプ | AM | |||||||||||||
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| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | application/pdf | |||||||||||||
| ID(XooNIps) | ||||||||||||||
| 23204249 | ||||||||||||||
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| 410 | ||||||||||||||
