| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2013-02-28 |
| タイトル |
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タイトル |
Endogenous orexin-A in the brain mediates 2-deoxy-D-glucose-induced stimulation of gastric motility in freely moving conscious rats |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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主題Scheme |
Other |
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キーワード |
Orexin |
| キーワード |
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主題Scheme |
Other |
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キーワード |
Brain |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
Stomach |
| キーワード |
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主題Scheme |
Other |
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キーワード |
Motility |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
Intraluminal pressure wave |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
野津, 司
Tsuchiya, Yoshihiro
Kumei, Shima
Takakusaki, Kaoru
Ataka, Koji
Fujimiya, Mineko
奥村, 利勝
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| 著者 ローマ字 |
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Okumura, Toshikatsu |
| 著者 ローマ字 |
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en |
| 書誌情報 |
Journal of Gastroenterology
巻 47,
号 4,
p. 404-411,
発行日 2012-04-01
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| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0944-1174 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1007/s00535-011-0506-7 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
22170413 |
| 識別番号 その他 |
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内容記述タイプ |
Other |
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内容記述 |
PMID:22170413 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
BACKGROUND: Increasing evidence has indicated that brain orexin plays a vital role in the regulation of gastrointestinal (GI) physiology such as gastric acid secretion and GI motility. The aim of this study was to elucidate the effects and mechanisms of orexin on gastric motility in non-fasted rats. \nMETHODS: In this study, we recorded intraluminal gastric pressure waves in freely moving conscious rats with a manometric catheter located in the antrum. We assessed the area under the manometric trace as the motor index (MI), and compared its values for 1 h before and after drug administration. \nRESULTS: Intracisternal (ic) injection of orexin-A (10 μg) significantly increased the MI, but intraperitoneal (ip) injection did not have any effect. Pretreatment of ip injection of atropine significantly blocked the orexin-A-induced stimulation of gastric motility. Intravenous injection of 2-deoxy-D-glucose (2-DG, 200 mg/kg), a central vagal stimulant, significantly increased the MI. The ic injection of SB-334687 (40 μg), a selective orexin-A antagonist, did not modify the basal MI, but this antagonist significantly suppressed the stimulant action of 2-DG. \nCONCLUSIONS: These results suggest that endogenous orexin-A in the brain is involved in the vagal-dependent stimulation of gastric contractions. |
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言語 |
en |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
Author |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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22170413 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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|
804 |
5071.pdf (524.6 kB)
