| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2013-02-25 |
| タイトル |
|
|
タイトル |
Unique Properties of Hepatocarcinogenesis-Resistant DRH Rat Hepatocytes Linked or Not Linked to the Drh1 Locus on Rat Chromosome |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
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資源タイプ |
journal article |
| 著者 |
Hashimoto, Norikazu
Yamamoto, Masahiro
Miyakoshi, Masaaki
Tanaka, Hiroki
Ogawa, Katsuhiro
|
| 書誌情報 |
International journal of hepatology
巻 2011,
p. 424356,
発行日 2011-01-01
|
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2090-3456 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.4061/2011/424356 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Hepatocarcinogenesis-resistant DRH rats exhibit few and small preneoplastic hepatocytic lesions during hepatocarcinogenesis, of which traits have been assigned to two major chromosomal regions, Drh1 and Drh2. In this study, hepatocytes from DRH.F344-Drh1, a congenic strain in which the Drh1 chromosomal region was replaced with that of F344 rats, were compared to hepatocytes from Donryu (original strain), DRH, and F344 rats. Although DRH hepatocytes exhibited low proliferation and p38 dephosphorylation after lead nitrate (LN) treatment despite cytokine and Cox2 activation, DRH.F344-Drh1 hepatocytes exhibited high responses, as did Donryu and F344 hepatocytes. Moreover, although DRH hepatocytes were resistant to hepatotoxins, DRH.F344-Drh1 hepatocytes were as sensitive to hepatotoxins as Donryu and F344 hepatocytes. However, DRH.F344-Drh1 hepatocytes like DRH hepatocytes proliferated at lower rates in vitro and contained smaller nuclei than Donryu and F344 hepatocytes. Thus, low responses to LN and resistance to hepatotoxins in DRH hepatocytes were linked to the Drh1 locus, while low proliferation in vitro and small nuclear size were not linked to the Drh1 locus. |
|
言語 |
en |
| 注記 |
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|
内容記述タイプ |
Other |
|
注記 |
Publisher |
| 資源タイプ |
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内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
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|
出版タイプ |
VoR |
| フォーマット |
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|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| ID(XooNIps) |
|
|
|
21994856 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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|
912 |
5060.pdf (3.8 MB)
