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Single cytomegalovirus strain associated with fetal loss and then congenital infection of a subsequent child born to the same mother

https://asahikawa-med.repo.nii.ac.jp/records/4305
https://asahikawa-med.repo.nii.ac.jp/records/4305
0a281e39-eeed-434d-88dd-ca011fe3a5bb
名前 / ファイル ライセンス アクション
5059.pdf 5059.pdf (259.9 kB)
Item type 学術雑誌論文 / Journal Article_02(1)
公開日 2013-02-25
タイトル
タイトル Single cytomegalovirus strain associated with fetal loss and then congenital infection of a subsequent child born to the same mother
言語 en
言語
言語 eng
キーワード
主題Scheme Other
キーワード Congenital cytomegalovirus infection
キーワード
主題Scheme Other
キーワード Neonatal screening
キーワード
主題Scheme Other
キーワード Transmission
キーワード
主題Scheme Other
キーワード Siblings
キーワード
主題Scheme Other
キーワード Viral reactivation
資源タイプ
資源タイプ journal article
著者 長森, 恒久

× 長森, 恒久

ja 長森, 恒久

ja-Kana ナガモリ, ツネヒサ

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Koyano, Shin

× Koyano, Shin

en Koyano, Shin

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Inoue, Naoki

× Inoue, Naoki

en Inoue, Naoki

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Yamada, Hideto

× Yamada, Hideto

en Yamada, Hideto

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Ohshima, Miho

× Ohshima, Miho

en Ohshima, Miho

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Minematsu, Toshio

× Minematsu, Toshio

en Minematsu, Toshio

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Fujieda, Kenji

× Fujieda, Kenji

en Fujieda, Kenji

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書誌情報 Journal of Clinical Virology

巻 49, 号 2, p. 134-136, 発行日 2010-10-01
ISSN
収録物識別子タイプ PISSN
収録物識別子 1386-6532
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.1016/j.jcv.2010.06.021
PubMed番号
識別子タイプ PMID
関連識別子 20685160
抄録
内容記述タイプ Abstract
内容記述 BACKGROUND: Intrauterine transmission of cytomegalovirus (CMV) can occur even in CMV-seropositive mothers. Previous studies demonstrated re-infection with a newly acquired CMV strain during pregnancy had a major role in such transmission. Although reactivation of latently infected CMV is another plausible cause, no direct evidence has been documented. \nOBJECTIVES: We sought to identify the route(s) and maternal risk factor of CMV infection that occurred in consecutive pregnancies and resulted in symptomatic congenital infections. \nSTUDY DESIGN: A newborn identified with congenital CMV infection in our newborn screening program developed hearing loss and subsequent nystagmus. The mother had a history of an elective abortion due to a severe fetal CMV infection 32 months prior to delivery of this newborn. We analyzed maternal serological changes and compared CMV genomic sequences in specimens obtained from the aborted fetus and the present case. We also analyzed immunological functions of the mother. \nRESULTS: Our major findings were as follows: (1) the aborted fetus and the present case were infected with the same strain. (2) The congenital infection that resulted in the abortion was due to a primary infection. (3) CMV DNA was undetectable in the mother's blood from 3 months after the abortion. These results strongly suggested that maternal viral reactivation caused the congenital infection in the present case. However, we could not find impairment of immunological functions in the mother. \nCONCLUSIONS: Viral reactivation in an apparently immunocompetent mother can cause symptomatic congenital CMV infection.
言語 en
注記
内容記述タイプ Other
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内容記述タイプ Other
資源タイプ text
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出版タイプ VoR
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内容記述タイプ Other
内容記述 application/pdf
ID(XooNIps)
20685160
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ダウンロード数(XooNIps)
695
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