| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2013-02-25 |
| タイトル |
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タイトル |
Sequential changes in pathophysiology of systemic inflammatory response in a disseminated neonatal herpes simplex virus (HSV) infection |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
Neonatal HSV infection |
| キーワード |
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主題Scheme |
Other |
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キーワード |
Sepsis |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
Anti-inflammatory intervention |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
HMGB1 |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
Cytochrome c |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
長森, 恒久
Koyano, Shin
Asai, Yoko
Nohara, Fumikatsu
Okamoto, Toshio
Nagaya, Ken
Hayashi, Tokitsugi
Miura, Yurika
Tsuda, Naoya
Iseki, Kenichi
東, 寛
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| 著者 ローマ字 |
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Azuma, Hiroshi |
| 著者 ローマ字 |
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en |
| 書誌情報 |
Journal of Clinical Virology
巻 53,
号 3,
p. 265-267,
発行日 2012-03-01
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| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1386-6532 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.jcv.2011.12.017 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
22237001 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
BACKGROUND: Disseminated neonatal herpes simplex virus (HSV) infection causes a typical systemic inflammatory response syndrome and has a high mortality rate. However, the validity of anti-inflammatory intervention against this condition remains unknown. \nOBJECTIVES: We sought to demonstrate the sequential changes in the pathophysiology of disseminated neonatal HSV infections. \nSTUDY DESIGN: The HSV serum copy number as well as high-mobility group box 1 (HMGB1) and cytochrome c concentrations, which predict the severity and mortality rate of sepsis, were sequentially evaluated in a patient with disseminated neonatal HSV infection caused by HSV-2. \nRESULTS: As the patient presented with evidence of hyper-inflammation and severe illness, we empirically undertook anti-inflammatory intervention that included the administration of prednisolone, high-dose immunoglobulin, and blood exchange therapy in addition to high-dose acyclovir (ACV) therapy. The patient survived without significant neurological sequela. We found that (1) the serum concentrations of both HMGB1 and cytochrome c were extremely high, (2) temporal increases in these biomarkers were observed after admission, and (3) interestingly, the increase in HMGB1 level preceded that of cytochrome c. These results suggested that the pathophysiology of this condition changed sequentially in a dramatic manner, and the timing of our anti-inflammatory intervention was prior to the transition of pathological status from hyper-inflammation to massive apoptosis. \nCONCLUSIONS: Anti-inflammatory intervention may only be effective if it is undertaken during the early phase of disseminated neonatal HSV infections. |
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言語 |
en |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
Author |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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22237001 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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508 |
5058.pdf (349.7 kB)
