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Six-transmembrane epithelial antigen of the prostate and enhancer of zeste homolog 2 as immunotherapeutic targets for lung cancer
https://asahikawa-med.repo.nii.ac.jp/records/4257
https://asahikawa-med.repo.nii.ac.jp/records/425714b47a6e-008f-41e5-8e6c-614f94998825
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4995.pdf (243.8 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||||||||||||||||
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| 公開日 | 2013-01-25 | |||||||||||||||||||||||||||
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| タイトル | Six-transmembrane epithelial antigen of the prostate and enhancer of zeste homolog 2 as immunotherapeutic targets for lung cancer | |||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||
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| 資源タイプ | journal article | |||||||||||||||||||||||||||
| 著者 |
林, 諭史
× 林, 諭史
× Kumai, T
× Matsuda, Y
× Aoki, N
× Sato, K
× Kimura, S
× Kitada, M
× Tateno, M
× Celis, E
× Kobayashi, H
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| 書誌情報 |
Journal of translational medicine 巻 5, 号 9, p. 191, 発行日 2011-11-01 |
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| 収録物識別子タイプ | PISSN | |||||||||||||||||||||||||||
| 収録物識別子 | 1479-5876 | |||||||||||||||||||||||||||
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| 識別子タイプ | DOI | |||||||||||||||||||||||||||
| 関連識別子 | 10.1186/1479-5876-9-191 | |||||||||||||||||||||||||||
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| 識別子タイプ | PMID | |||||||||||||||||||||||||||
| 関連識別子 | 22053850 | |||||||||||||||||||||||||||
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| 内容記述タイプ | Abstract | |||||||||||||||||||||||||||
| 内容記述 | Background T-cell based immunotherapy for lung cancer (LC) could be a promising and novel therapeutic approach. Six-transmembrane epithelial antigen of the prostate (STEAP) and the polycomb group protein enhancer of zeste homolog 2 (EZH2) are highly expressed in LC and since the expression of molecules in normal tissue is significantly lower as compared to tumor cells, these proteins are considered as potential tumor-associated antigens (TAAs) for developing T-cell based immunotherapy. \nMethods We assessed the capacity of predicted CD4 T-cell epitopes from STEAP and EZH2 to induce anti-tumor immune responses to LC cell lines. \nResults Out of several predicted epitopes, two synthetic peptides, STEAP281-296 and EZH295-109, were effective in inducing CD4 T-cell responses that were restricted by HLA-DR1, DR15, or DR53 molecules, indicating that the peptides function as promiscuous T-cell epitopes. Moreover, STEAP281-296 and EZH295-109-reactive T-cells could directly recognize STEAP or EZH2 expressing LC cells in an HLA-DR restricted manner. In addition, some STEAP-reactive T-cells responded to STEAP+ tumor cell lysates presented by autologous dendric cells. Most significantly, both of these peptides were capable of stimulating in vitro T-cell responses in patients with LC. \nConclusions Peptides STEAP281-296 and EZH295-109 function as strong CD4 T-cell epitopes that can elicit effective anti-tumor T-cell responses against STEAP or EZH2 expressing LC. These observations may facilitate the translation of T-cell based immunotherapy into the clinic for the treatment of LC. | |||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||||||||
| 資源タイプ | text | |||||||||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||||||||||||||
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| 22053850 | ||||||||||||||||||||||||||||
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| ダウンロード数(XooNIps) | ||||||||||||||||||||||||||||
| 321 | ||||||||||||||||||||||||||||
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林, 諭史, Kumai, T, Matsuda, Y, Aoki, N, Sato, K, Kimura, S, Kitada, M, Tateno, M, Celis, E, Kobayashi, H, n.d., Six-transmembrane epithelial antigen of the prostate and enhancer of zeste homolog 2 as immunotherapeutic targets for lung cancer: 191– p.
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