| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2013-01-25 |
| タイトル |
|
|
タイトル |
Lamellar granule secretion starts before the establishment of tight junction barrier for paracellular tracers in mammalian epidermis |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
山本, 明美
Kishibe, M
Murakami, M
Honma, M
Takahashi, H
Iizuka, H
|
| 書誌情報 |
PloS one
巻 7,
号 2,
p. e31641,
発行日 2012-02-01
|
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1932-6203 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1371/journal.pone.0031641 |
| PubMed番号 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
22328942 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Defects in epidermal barrier function and/or vesicular transport underlie severe skin diseases including ichthyosis and atopic dermatitis. Tight junctions (TJs) form a single layered network in simple epithelia. TJs are important for both barrier functions and vesicular transport. Epidermis is stratified epithelia and lamellar granules (LGs) are secreted from the stratum granulosum (SG) in a sequential manner. Previously, continuous TJs and paracellular permeability barriers were found in the second layer (SG2) of SG in mice, but their fate and correlation with LG secretion have been poorly understood. We studied epidermal TJ-related structures in humans and in mice and found occludin/ZO-1 immunoreactive multilayered networks spanning the first layer of SG (SG1) and SG2. Paracellular penetration tracer passed through some TJs in SG2, but not in SG1. LG secretion into the paracellular tracer positive spaces started below the level of TJs of SG1. Our study suggests that LG-secretion starts before the establishment of TJ barrier in the mammalian epidermis. |
|
言語 |
en |
| 注記 |
|
|
内容記述タイプ |
Other |
|
注記 |
Publisher |
| 資源タイプ |
|
|
内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| ID(XooNIps) |
|
|
|
22328942 |
| 閲覧数(XooNIps) |
|
| ダウンロード数(XooNIps) |
|
|
|
929 |
4994.pdf (2.8 MB)
