| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2013-01-24 |
| タイトル |
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|
タイトル |
Replacement of liver parenchyma in analbuminemic rats with allogenic hepatocytes is facilitated by intrabone marrow-bone marrow transplantation |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
Analbuminemic F344 rats |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
Intrabone marrow-bone marrow transplantation |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
Allogenic hepatocyte transplantation |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
Retrorsine |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
Partial hepatectomy |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
稲垣, 光裕
Furukawa, Hiroyuki
Satake, Yoshiyasu
Okada, Yoko
Chiba, Shinichi
Nishikawa, Yuji
Ogawa, Katsuhiro
|
| 書誌情報 |
Cell Transplantation
巻 20,
号 9,
p. 1479-1489,
発行日 2011-01-01
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| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0963-6897 |
| DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.3727/096368910X547453 |
| 識別番号 その他 |
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内容記述タイプ |
Other |
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内容記述 |
PMID：21176395 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Although hepatocyte transplantation (HCTx) is expected to become a useful therapy for human liver diseases, allogenic hepatocytes still tend to be rejected within a short period due to host immunosurveillance. In the present study, we investigated the effect of prior bone marrow transplantation (BMTx) for the engraftment of allogenic hepatocytes using the analbuminemic rat transplantation model. The hepatocytes of Lewis (LEW) rats were not accepted in the liver of retrorsine (RS)/partial hepatectomy (PH)-treated analbuminemic F344 (F344-alb) rats, which express the disparate major histocompatibility complex (MHC) against that of LEW rats. Prior BMTx with the LEW bone marrow cells (BMCs) after sublethal irradiation achieved acceptance and repopulation of LEW hepatocytes in the liver of the RS/PH-treated F344-alb rats, associated with elevation of serum albumin. The replacement of hepatic parenchyma with albumin positive (Alb+) donor hepatocytes and elevation of serum albumin levels were dependent on the bone marrow reconstitution by donor BMCs, which was more efficiently achieved by intrabone marrow (IBM)-BMTx than by intravenous (IV)-BMTx. Our results demonstrate that efficient bone marrow reconstitution by IBM-BMTx enables the replacement of the hepatic parenchyma with allogenic hepatocytes in RS/PH-treated analbuminemic rats without immunosuppressants. |
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言語 |
en |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
Publisher |
| 資源タイプ |
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内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
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|
出版タイプ |
VoR |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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|
21176395 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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|
459 |
4993.pdf (6.6 MB)
