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Acrosyringium Is the Main Site of the Vesicle/Pustule Formation in Palmoplantar Pustulosis
https://asahikawa-med.repo.nii.ac.jp/records/4047
https://asahikawa-med.repo.nii.ac.jp/records/4047be3a53ac-6167-4a84-95d0-ca97e8d09f91
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
4541.pdf (5.5 MB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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| 公開日 | 2012-05-17 | |||||
| タイトル | ||||||
| タイトル | Acrosyringium Is the Main Site of the Vesicle/Pustule Formation in Palmoplantar Pustulosis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
村上, 正基
× 村上, 正基× Ohtake, Takaaki× Horibe, Yoshimune× Ishida-Yamamoto, Akemi× Morhenn, Vera B.× Gallo, Richard L.× Iizuka, Hajime |
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| 書誌情報 |
Journal of Investigative Dermatology 巻 130, 号 8, p. 2010-2016, 発行日 2010-08-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0022-202X | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/jid.2010.87 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Pustulosis palmaris et plantaris or palmoplantar pustulosis (PPP) is a refractory pustular eruption on the palms and soles with unknown etiology. Numerous eccrine sweat pores exist on the palms and soles, suggesting the involvement of eccrine sweating in the pathogenesis of PPP. To the best of our knowledge, however, no definite abnormality in sweating has been documented in PPP. Accordingly, we analyzed the eccrine sweat duct involvement in the mechanism of vesicle formation in PPP. Dermatoscopy showed that PPP vesicles are located on the top of the ridges but not in the furrows. The sweat secretion in the lesional area was much lower than that in the nonlesional area, with or without pain stimulation to induce sweating. Immunostaining of horizontal sections of the lesions using antibodies against gross cystic disease fluid protein-15 (GCDFP-15) and epithelial membrane antigen (EMA) showed that these markers were localized in the cells lining the intraepidermal vesicles. Although the sweat antimicrobial peptides, dermcidin and human cathelicidin antimicrobial peptide 18 (hCAP-18)/LL-37, were detected in the fluid of the vesicles/pustules, neither dermcidin nor hCAP-18/LL-37 were overexpressed by neighboring keratinocytes. These findings suggest that the acrosyringium may be involved as the main site of the vesicle formation in the pathomechanism of PPP. | |||||
| 言語 | en | |||||
| 注記 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://dx.doi.org/10.1038/jid.2010.87 © 2010 Society for Investigative Dermatology | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| ID(XooNIps) | ||||||
| 値 | 20393482 | |||||
| 閲覧数(XooNIps) | ||||||
| 値 | 1433 | |||||
| ダウンロード数(XooNIps) | ||||||
| 値 | 1074 | |||||
