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Mechanisms by which thiazolidinediones induce anti-cancer effects in cancers in digestive organs
https://asahikawa-med.repo.nii.ac.jp/records/4013
https://asahikawa-med.repo.nii.ac.jp/records/4013bdaecad7-e965-4248-9480-1c47fda50846
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
4472.pdf (266.9 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||
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| 公開日 | 2012-05-17 | |||||||||
| タイトル | ||||||||||
| タイトル | Mechanisms by which thiazolidinediones induce anti-cancer effects in cancers in digestive organs | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
奥村, 利勝
× 奥村, 利勝
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| 書誌情報 |
Journal of Gastroenterology 巻 45, 号 11, p. 1097-1102, 発行日 2010-11-01 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 0944-1174 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isVersionOf | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1007/s00535-010-0310-9 | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Increasing evidence suggests that thiazolidinediones (TZDs) could have a therapeutic potential for patients with cancers. Here, the evidence on the mechanisms by which TZDs could contribute to different steps of cancer biology in the digestive system is summarized. According to studies, TZDs induce anti-cancer actions through 3 main pathways: (1) cell growth arrest, (2) induction of apoptosis, and (3) inhibition of cell invasion. Cell growth arrest is induced by an increased level of p27^<Kip1>. p27^<Kip1> accumulation results from the inhibition of the ubiquitin-proteasome system and/or inhibition of MEK–ERK signaling. TZDs induce apoptosis through increased levels of apoptotic molecules, such as p53 and PTEN and/or decreased level of anti-apoptotic molecules, such as Bcl-2 and survivin. Inhibition of MEK–ERK signaling-mediated up-regulation of E-cadherin and claudin-4, and/or decreased expression of matrix metalloproteinases (MMPs) such as MMP-2 and MMP-9, play a role in the TZD-induced inhibition of cancer cell invasion. Thus, TZDs are capable of inducing anti-tumor action in a variety of ways in gastrointestinal cancers. | |||||||||
| 言語 | en | |||||||||
| 注記 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 注記 | http://dx.doi.org/10.1007/s00535-010-0310-9 The original publication is available at springerlink.com | |||||||||
| 資源タイプ | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 資源タイプ | text | |||||||||
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| 出版タイプ | AM | |||||||||
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| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
| ID(XooNIps) | ||||||||||
| 20824291 | ||||||||||
| 閲覧数(XooNIps) | ||||||||||
| ダウンロード数(XooNIps) | ||||||||||
| 403 | ||||||||||
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Cite as
奥村, 利勝, n.d., Mechanisms by which thiazolidinediones induce anti-cancer effects in cancers in digestive organs: 1097–1102 p.
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