| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2012-07-31 |
| タイトル |
|
|
タイトル |
Order and disorder in corneocyte adhesion |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
山本, 明美
Igawa, Satomi
Kishibe, Mari
|
| 書誌情報 |
The Journal of Dermatology
巻 38,
号 7,
p. 645-654,
発行日 2011-07-01
|
| ISSN |
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|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0385-2407 |
| DOI |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1111/j.1346-8138.2011.01227.x |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
The definitive version is available at www.blackwell-synergy.com. | The definitive version is available at www.blackwell-synergy.com. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Epidermal cornified cells are attached to each other with modified desmosomes, namely corneodesmosomes. Changes in the corneodesmosome degradation process influence the total thickness of the stratum corneum and surface appearance of the skin. The major extracellular constituents of corneodesmosomes are desmoglein 1, desmocollin 1 and corneodesmosin. The intracellular part of corneodesmosomes is cross-linked into cornified cell envelopes. Corneodesmosomes are degraded from the central surface area of each cell. Peripheral corneodesmosomes retain structural integrity up to the skin surface. A hypothesis where tight junctions in the stratum corneum play a role in this spatial difference in corneodesmosome degradation has recently been proposed. Genetic defects in corneodesmosin and inhibitors for proteases involved in corneodesmosome degradation result in accelerated desquamation and severe barrier impairment, presenting as the inflammatory type of peeling skin syndrome and Netherton syndrome, respectively. Abnormal corneodesmosome degradation is also found in more common skin diseases including ichthyosis vulgaris, atopic dermatitis, psoriasis vulgaris, lichen planus and soap-induced xerosis. |
|
言語 |
en |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
© 2011 Japanese Dermatological Association |
| 資源タイプ |
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|
内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
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|
出版タイプ |
AM |
| フォーマット |
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|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| ID(XooNIps) |
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|
21545505 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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|
575 |
4721.pdf (682.9 kB)
