| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2012-05-30 |
| タイトル |
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|
タイトル |
Primary cutaneous γδ-T-cell lymphoma treated with low-dose methotrexate and narrowband ultraviolet B irradiation: Report of a case with testicular involvement |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
藤井, 瑞恵
Uehara, Jiro
Honma, Masaru
Ito, Yasuhiro
Takahashi, Hidetoshi
Yamamoto-Ishida, Akemi
Iizuka, Hajime
|
| 書誌情報 |
The Journal of Dermatology
巻 38,
号 4,
p. 368-372,
発行日 2011-04-01
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| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0385-2407 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1111/j.1346-8138.2010.00998.x |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
The definitive version is available at www.blackwell-synergy.com. | The definitive version is available at www.blackwell-synergy.com. |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
http://www.ncbi.nlm.nih.gov/pubmed/21352347 | http://www.ncbi.nlm.nih.gov/pubmed/21352347 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Primary cutaneous γδ-T-cell lymphoma (CGD-TCL) is a rare entity of cutaneous T-cell lymphomas (CTCL) and is characterized by tumoral growth of mature γδ-T-cell expressing cytotoxic molecules. The prognosis of CGD-TCL is generally worse than other CTCL. However, relatively indolent patch/plaque lesions have been described suggesting the heterogeneous nature of this entity. Here, we present a case of CGD-TCL with various skin manifestations, such as erythematous plaques/tumors and subcutaneous panniculitis-like lesions. During the follow up, testicular involvement was detected, which was surgically removed. Histopathology showed mixed features from epidermotropism, dermal infiltration and subcutaneous panniculitis-like lesions depending on the clinical manifestations. The tumor cells were positive for CD3 and revealed cytotoxic markers, TIA-1 and perforin, but not for CD4, CD8, CD20, CD56, TCRβF1 or EBER. Topical glucocorticoid ointment, narrowband ultraviolet B (NB-UVB) irradiation and low-dose methotrexate (MTX) were effective to control these skin lesions. No visceral involvement was detected thereafter. While CGD-TCL is usually associated with poor prognosis, it seems to be composed of various clinical manifestations, and NB-UVB and low-dose MTX could be a choice for indolent patch/plaque and possibly nodular lesions, especially for the aged. |
|
言語 |
en |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
© 2010 Japanese Dermatological Association |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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21352347 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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538 |
4730.pdf (187.1 kB)
