| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2012-08-02 |
| タイトル |
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タイトル |
Localization of the Most Severely Dysplastic/Invasive Lesions and Mucin Phenotypes in Intraductal Papillary Mucinous Neoplasm of the Pancreas |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
唐崎, 秀則
Mizukami, Yusuke
Tokusashi, Yoshihiko
Koizumi, Kazuya
Ishizaki, Akira
Imai, Kouji
Yoshikawa, Daitaro
Kino, Shuichi
Sasajima, Junpei
Tanno, Satoshi
Matsumoto, Kakuya
Miyokawa, Naoyuki
Kono, Toru
Kohgo, Yutaka
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| 日付 作成日 |
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|
日付 |
2012-05-30 |
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日付タイプ |
Created |
| 書誌情報 |
Pancreas
巻 40,
号 4,
p. 588-594,
発行日 2011-05-01
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| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0885-3177 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1097/MPA.0b013e31820d1a03 |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
http://journals.lww.com/pancreasjournal/pages/default.aspx | http://journals.lww.com/pancreasjournal/pages/default.aspx |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://www.ncbi.nlm.nih.gov/pubmed/21441843 | http://www.ncbi.nlm.nih.gov/pubmed/21441843 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Objective: The aim of this study was to define the relevance of mural nodules (MNs) as a "direct" indicator of malignancy of intraductal papillary mucinous neoplasm (IPMN) of the pancreas. Methods: Thirty-nine surgically resected IPMNs excluding obviously invasive carcinomas were examined. The distribution of the most severely dysplastic lesions was mapped on specimens. Immunohistochemical analysis for MUC1 and MUC2 was performed on sections containing the histologically predominant lesions and the most severely dysplastic areas. Results: The presence of MNs correlated well with the histological grade of IPMN (P < 0.01); however, the most severely dysplastic lesions were associated with a flat/nonelevated area rather than MNs (78.9%). In the MUC1-positive subgroup, minimally invasive carcinoma was colocalized to MNs, whereas most severely dysplastic foci including minimally invasive carcinoma with components of mucinous and tubular adenocarcinoma were observed in the areas apart from MNs in the MUC2-positive and MUC1/2-negative subgroups, respectively. Conclusions: Although our data support the concept that MNs represent areas of higher-grade dysplasia within IPMN, development of invasive lesions from MNs may be limited to cases that are MUC1-positive. Careful attention should be paid to the emergence of invasive IPMN from flat foci in MUC2-positive and MUC1/2-negative cases. |
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言語 |
en |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
This is a non-final version of an article published in final form in Karasaki, Hidenori ; Mizukami, Yusuke ; Tokusashi, Yoshihiko ; Koizumi, Kazuya ; Ishizaki, Akira ; Imai, Kouji ; Yoshikawa, Daitaro ; Kino, Shuichi ; Sasajima, Junpei ; Tanno, Satoshi ; Matsumoto, Kakuya ; Miyokawa, Naoyuki ; Kono, Toru ; Kohgo, Yutaka ; Furukawa, Hiroyuki, Pancreas, 40(4), 588-594. |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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21441843 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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714 |
4731.pdf (789.2 kB)
