| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2012-06-28 |
| タイトル |
|
|
タイトル |
Retrospective Comparison of the Efficacy of Tonsillectomy with and without Steroid-pulse Therapy in IgA Nephropathy Patients. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
clinical remission |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
IgA nephropathy |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
methylprednisolone pulse |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
tonsillectomy |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
中川, 直樹
Kabara, Maki
Matsuki, Motoki
Chinda, Junko
Fujino, Takayuki
Hirayama, Tomoya
Takahara, Miki
Harabuchi, Yasuaki
Kikuchi, Kenjiro
Hasebe, Naoyuki
|
| 書誌情報 |
Internal Medicine
巻 51,
号 11,
p. 1323-1328,
発行日 2012-01-01
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0918-2918 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.2169/internalmedicine.51.7238 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Objective Tonsillectomy and steroid-pulse (TSP) therapy have been proposed as a curative treatment for immunoglobulin A nephropathy (IgAN) in Japan. However, we sometimes encounter patients who reject steroid-pulse therapy because of concerns about the side effects of corticosteroids. Here, we examined the efficacy of TSP therapy and tonsillectomy alone for IgAN with urinary abnormalities. Methods Data on 40 IgAN patients diagnosed by renal biopsies, who presented glomerular hematuria and proteinuria at baseline and underwent bilateral palatine tonsillectomy, were analyzed retrospectively. Twenty of them underwent TSP therapy (TSP group), and 20 underwent tonsillectomy alone (T group). We examined associations between therapies, changes in urinary findings and renal function, and subsequent clinical remission (CR), defined as negative proteinuria and urinary erythrocytes of less than 5/high-power field. Results TSP group showed a significant decrease in proteinuria and hematuria earlier than T group. The rates of CR were significantly higher in TSP group compared with T group on the final observation period (75% vs. 45%, p<0.05). There was a significant difference between CR group and non-CR group only in the rate of receiving TSP therapy. Conclusion TSP therapy significantly increased the probability of CR compared with tonsillectomy alone in IgAN patients with urinary abnormalities. |
|
言語 |
en |
| 注記 |
|
|
内容記述タイプ |
Other |
|
注記 |
著者最終原稿版 |
| 資源タイプ |
|
|
内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
|
|
出版タイプ |
AM |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| ID(XooNIps) |
|
|
|
Inter-Med-51-11-1323 |
| 閲覧数(XooNIps) |
|
| ダウンロード数(XooNIps) |
|
|
|
674 |
4633.pdf (192.2 kB)
