| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2012-06-27 |
| タイトル |
|
|
タイトル |
Potential impact of renin-angiotensin system inhibitors and calcium channel blockers on plasma high-molecular-weight adiponectin levels in hemodialysis patients |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
high-molecular-weight adiponectin |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
visceral obesity |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
renin–angiotensin system inhibitors |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
calcium channel blockers |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
hemodialysis patients |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
中川, 直樹
Yao, Naoyuki
Hirayama, Tomoya
Ishida, Mari
Ishida, Hironori
Wada, Atsushi
Fujino, Takayuki
Saijo, Yasuaki
Kikuchi, Kenjiro
Hasebe, Naoyuki
|
| 書誌情報 |
Hypertension Research
巻 34,
号 5,
p. 592-598,
発行日 2011-05-01
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0916-9636 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Although metabolic syndrome confers an increased risk of cardiovascular disease in the general population, little is known about the alteration of abdominal adiposity and its association with adipocytokines in hemodialysis patients. We investigated the plasma high-molecular-weight (HMW) adiponectin level and its relationship to visceral fat area (VFA) and various markers of atherosclerosis in hemodialysis patients. In a cross-sectional study, conventional cardiovascular risk factors, plasma total and HMW adiponectin, the number of components of the metabolic syndrome and, using computed tomography, the distribution of abdominal adiposity were assessed in 144 hemodialysis patients (90 men and 54 women; mean age, 60.7 years) and 30 age- and sex-matched patients with chronic kidney disease (CKD). Plasma HMW adiponectin levels in hemodialysis patients were significantly higher than those in patients with CKD, negatively associated with VFA and serum triglycerides and positively associated with plasma total adiponectin, as well as the HMW-to-total adiponectin ratio in men and women (all P < 0.05) in a simple regression analysis. In a multiple regression analysis, VFA was a significant determinant of HMW adiponectin in hemodialysis patients. Furthermore, after adjustment for classical risk factors, HMW adiponectin levels were significantly higher in patients undergoing treatment with renin-angiotensin system inhibitors or calcium channel blockers compared with patients not undergoing such treatment. This study shows that plasma HMW adiponectin levels were negatively associated with VFA and positively associated with treatment with blockade of the renin-angiotensin system and of the calcium channel. Therefore, these drugs might be effective for improving adipocytokine-related metabolic abnormalities in hemodialysis patients. |
|
言語 |
en |
| 注記 |
|
|
内容記述タイプ |
Other |
|
注記 |
著者最終原稿版 |
| 資源タイプ |
|
|
内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
|
|
出版タイプ |
AM |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| ID(XooNIps) |
|
|
|
M116290010 |
| 閲覧数(XooNIps) |
|
| ダウンロード数(XooNIps) |
|
|
|
698 |
4628.pdf (268.4 kB)
