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Potential impact of renin-angiotensin system inhibitors and calcium channel blockers on plasma high-molecular-weight adiponectin levels in hemodialysis patients
https://asahikawa-med.repo.nii.ac.jp/records/3911
https://asahikawa-med.repo.nii.ac.jp/records/391102ac2f5b-eba8-4770-90fd-5eb761985c49
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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公開日 | 2012-06-27 | |||||
タイトル | ||||||
タイトル | Potential impact of renin-angiotensin system inhibitors and calcium channel blockers on plasma high-molecular-weight adiponectin levels in hemodialysis patients | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | high-molecular-weight adiponectin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | visceral obesity | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | renin–angiotensin system inhibitors | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | calcium channel blockers | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | hemodialysis patients | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
中川, 直樹
× 中川, 直樹× Yao, Naoyuki× Hirayama, Tomoya× Ishida, Mari× Ishida, Hironori× Wada, Atsushi× Fujino, Takayuki× Saijo, Yasuaki× Kikuchi, Kenjiro× Hasebe, Naoyuki |
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書誌情報 |
Hypertension Research 巻 34, 号 5, p. 592-598, 発行日 2011-05-01 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0916-9636 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although metabolic syndrome confers an increased risk of cardiovascular disease in the general population, little is known about the alteration of abdominal adiposity and its association with adipocytokines in hemodialysis patients. We investigated the plasma high-molecular-weight (HMW) adiponectin level and its relationship to visceral fat area (VFA) and various markers of atherosclerosis in hemodialysis patients. In a cross-sectional study, conventional cardiovascular risk factors, plasma total and HMW adiponectin, the number of components of the metabolic syndrome and, using computed tomography, the distribution of abdominal adiposity were assessed in 144 hemodialysis patients (90 men and 54 women; mean age, 60.7 years) and 30 age- and sex-matched patients with chronic kidney disease (CKD). Plasma HMW adiponectin levels in hemodialysis patients were significantly higher than those in patients with CKD, negatively associated with VFA and serum triglycerides and positively associated with plasma total adiponectin, as well as the HMW-to-total adiponectin ratio in men and women (all P < 0.05) in a simple regression analysis. In a multiple regression analysis, VFA was a significant determinant of HMW adiponectin in hemodialysis patients. Furthermore, after adjustment for classical risk factors, HMW adiponectin levels were significantly higher in patients undergoing treatment with renin-angiotensin system inhibitors or calcium channel blockers compared with patients not undergoing such treatment. This study shows that plasma HMW adiponectin levels were negatively associated with VFA and positively associated with treatment with blockade of the renin-angiotensin system and of the calcium channel. Therefore, these drugs might be effective for improving adipocytokine-related metabolic abnormalities in hemodialysis patients. | |||||
言語 | en | |||||
注記 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 著者最終原稿版 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | text | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
ID(XooNIps) | ||||||
値 | M116290010 | |||||
閲覧数(XooNIps) | ||||||
値 | 1230 | |||||
ダウンロード数(XooNIps) | ||||||
値 | 698 |