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Mechanisms by which thiazolidinediones induce anti-cancer effects in cancers in digestive organs
https://asahikawa-med.repo.nii.ac.jp/records/3878
https://asahikawa-med.repo.nii.ac.jp/records/3878fb2f610b-4afa-4370-9231-448002ab6b21
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
4592.pdf (278.6 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||
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| 公開日 | 2012-06-06 | |||||||||
| タイトル | ||||||||||
| タイトル | Mechanisms by which thiazolidinediones induce anti-cancer effects in cancers in digestive organs | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| キーワード | thiazolidinedione (TZD) | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| キーワード | anti-cancer action | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| キーワード | digestive organs | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ | journal article | |||||||||
| その他（別言語等）のタイトル | ||||||||||
| その他のタイトル | Thiazolidinedioneが消化器癌において抗癌作用を誘導する機序 | |||||||||
| 言語 | ja | |||||||||
| 著者 |
奥村, 利勝
× 奥村, 利勝
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| 書誌情報 |
Journal of Gastroenterology 巻 45, 号 11, p. 1097-1102, 発行日 2010-11-01 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 0944-1174 | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Increasing evidence have suggested that thiazolidinediones (TZDs) could have a therapeutic potential for patients with cancers. Here, the evidence on the mechanisms by which TZDs could contribute to different steps of cancer biology in the digestive system was summarized. According to studies, TZDs induce anti-cancer actions through 3 main pathways 1) cell growth arrest, 2) induction of apoptosis and 3) inhibition of cell invasion. Cell growth arrest is induced by increased level of p27Kip1. p27Kip1 accumulation is resulted from the inhibition of the ubiqutin-proteasome system and/or inhibition of MEK-ERK signaling. TZDs induce apoptosis through increased levels of apoptotic molecules, such as p53 and PTEN and/or decreased level of anti-apoptotic molecules, such as Bcl-2 and survivin. Inhibition of MEK-ERK signaling-mediated up-regulation of E-cadherin and claudin-4, and/or decreased expression of matrix metalloproteinases (MMPs) such as MMP-2 and MMP-9, play a role in the TZD-induced inhibition of cancer cell invasion. Thus, TZDs are capable of inducing anti-tumor action in a variety of ways in gastrointestinal cancers. | |||||||||
| 言語 | en | |||||||||
| 注記 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 注記 | 著者最終原稿版 | |||||||||
| 資源タイプ | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 資源タイプ | text | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | AM | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
| ID(XooNIps) | ||||||||||
| 2011164923 | ||||||||||
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| ダウンロード数(XooNIps) | ||||||||||
| 287 | ||||||||||
