| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2012-05-14 |
| タイトル |
|
|
タイトル |
Podoplanin expression in wound and hyperproliferative psoriatic epidermis: Regulation by TGF-β and STAT-3 activating cytokines, IFN-γ, IL-6, and IL-22 |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
Proriasis |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
Wound healing |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
Cytokines |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
STAT |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
SMAD |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
本間, 大
Minami-Hori, Masako
Takahashi, Hidetoshi
Iizuka, Hajime
|
| 書誌情報 |
Journal of Dermatological Science
巻 65,
号 2,
p. 134-140,
発行日 2012-02-01
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0923-1811 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.jdermsci.2011.11.011 |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
http://www.sciencedirect.com/science/article/pii/S0923181111003276 | http://www.sciencedirect.com/science/article/pii/S0923181111003276 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Podoplanin (PDPN)/T1a/aggrus/PA2.26 antigen, a transmembranous glycoprotein, is a well-known lymphatic endothelial marker. Recent evidence indicates that PDPN is also expressed in keratinocytes especially of sebaceous glands. Objective: To verify expression-pattern and the regulatory mechanism of PDPN in human epidermal keratinocytes. Methods: PDPN-expression pattern was analyzed in normal and psoriatic epidermis by immunostaining. The regulatory mechanism of PDPN-expression of keratinocytes by cytokines was analyzed using specific inhibitors, siRNA, and adenoviral shRNA of signaling pathways. Results: In normal skin, PDPN was expressed on the basal cell layer of sebaceous glands and on the outer root sheath of hair follicles. While no expression was detected in the normal interfollicular epidermis, PDPN was detected in the basal cell layer of wound and hyperproliferative psoriatic epidermis, where the granular layer is lacking. TGF-b1 and IFN-g independently upregulated PDPN-expression of keratinocytes via TGF-b receptor-Smad pathway and JAK-STAT pathway, respectively. IL-6 and IL-22 also stimulated PDPN-expression of keratinocytes accompanied by STAT-3 phosphorylation. siRNA of STAT-1, inhibitors of STAT-3 signaling, AG490, STAT-3 inhibitor VI, and si/shRNA of STAT-3 inhibited the PDPN-expression of keratinocytes induced by IFN-g, IL-6 and IL-22 but not by TGF-b1. Conclusion: These results indicate that TGF-b1, IFN-g, IL-6, and IL-22 induce PDPN-expression of keratinocytes, which might be significantly involved in the wound healing process as well as in the pathomechanism of hyperproliferative psoriatic epidermis. |
|
言語 |
en |
| 注記 |
|
|
内容記述タイプ |
Other |
|
注記 |
Author |
| 資源タイプ |
|
|
内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
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|
出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| ID(XooNIps) |
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|
22189341 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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|
1143 |
4401.pdf (1.8 MB)
