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Meiotic stage-dependent induction of chromosome aberrations in Chinese hamster primary oocytes exposed to topoisomerase II inhibitor etoposide
https://asahikawa-med.repo.nii.ac.jp/records/3352
https://asahikawa-med.repo.nii.ac.jp/records/335241dc04ab-29c1-4593-bf9e-a846b238c4a0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
434.pdf (690.6 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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| 公開日 | 2007-04-12 | |||||
| タイトル | ||||||
| タイトル | Meiotic stage-dependent induction of chromosome aberrations in Chinese hamster primary oocytes exposed to topoisomerase II inhibitor etoposide | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
立野, 裕幸
× 立野, 裕幸× Kamiguchi, Y |
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| 著者 ローマ字 | ||||||
| 値 | Tateno, Hiroyuki | |||||
| 著者 ローマ字 | ||||||
| 言語 | en | |||||
| 書誌情報 |
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 巻 476, 号 1-2, p. 139-148, 発行日 2001-05-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0027-5107 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/S0027-5107(01)00101-4 | |||||
| リンクURL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.sciencedirect.com/science/journal/00275107 | http://www.sciencedirect.com/science/journal/00275107 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To investigate the chromosomal effects of topoisomerase II-interactive drugs on mammalian primary oocytes, female Chinese hamsters were treated with etoposide (VP-16) at various intervals pre- and post-human chorionic gonadotropin (hCG) injections. Chromosome analysis of oocytes at metaphase II showed that treatment with VP-16 at 50 h pre-hCG had no effect, but the treatments between 24 h pre-hCG and 2 h post-hCG often caused structural chromosome berrations. Although treatment at 4 h post-hCG had no effect, subsequent treatments at 6 h and 8 h post-hCG produced a significant increase in structural chromosome aberrations. No effect was found following treatment at 10 h post-hCG. The incidence of aneuploidy following exposure to VP-16 was also dependent on the time of hCG injection. Taking the time course of meiotic progression in primary oocytes following hCG injection and pharmacokinetics of VP-16 into consideration, it is likely that meiotic stages from late dictyate to diakinesis are highly sensitive to VP-16, while stages at dictyate and from metaphase I to telophase I are relatively insensitive to the drug. Moreover, the effect of VP-16 on structural chromosome aberrations and aneuploidy was dose-dependent. Chromosome analysis at metaphase I detected a frequent occurrence of structural chromosome aberrations in treated oocytes. This suggests that structural aberrations may be caused by disruption of cleavable complexes during chromosome condensation. Detection of chromosome bridges during anaphase I/telopahse I may support the hypothesis that induction of aneuploidy by VP-16 is due to failure in decatenation of recombinant homologous chromosomes. | |||||
| 言語 | en | |||||
| 注記 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Elsevier Science B.V., Hiroyuki Tateno and Yujiroh Kamiguchi, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 476(1-2), 2001, 139-148. author | |||||
| 言語 | en | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| ID(XooNIps) | ||||||
| 値 | 11336991 | |||||
| 閲覧数(XooNIps) | ||||||
| 値 | 1408 | |||||
| ダウンロード数(XooNIps) | ||||||
| 値 | 720 | |||||
