| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2007-02-14 |
| タイトル |
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タイトル |
Tachycardia-induced myocardial ischemia and diastolic dysfunction potentiate secretion of ANP, not BNP, in hypertrophic cardiomyopathy |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
木戸, 伸介
Hasebe, N
Ishii, Y
Kikuchi, K
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| 著者 ローマ字 |
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Kido, Shinsuke |
| 著者 ローマ字 |
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en |
| 書誌情報 |
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
巻 290,
号 3,
p. H1064-H1070,
発行日 2006-03-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0363-6135 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1152/ajpheart.00110.2005 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://ajpheart.physiology.org/cgi/content/abstract/290/3/H1064?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=290&firstpage=H1064&resourcetype=HWCIT | http://ajpheart.physiology.org/cgi/content/abstract/290/3/H1064?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=290&firstpage=H1064&resourcetype=HWCIT |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The aim of this study was to investigate what factor determines tachycardia-induced secretion of atrial and brain natriuretic peptides (ANP and BNP, respectively) in patients with hypertrophic cardiomyopathy (HCM). HCM patients with normal left ventricular (LV) systolic function and intact coronary artery (n = 22) underwent rapid atrial pacing test. The cardiac secretion of ANP and BNP and the lactate extraction ratio (LER) were evaluated by using blood samples from the coronary sinus and aorta. LV end-diastolic pressure (LVEDP) and the time constant of LV relaxation of tau were measured by a catheter-tip transducer. These parameters were compared with normal controls (n = 8). HCM patients were divided into obstructive (HOCM) and nonobstructive (HNCM) groups. The cardiac secretion of ANP was significantly increased by rapid pacing in HOCM from 384 ± 101 to 1,268 ± 334 pg/ml (P < 0.05); however, it was not significant in control and HNCM groups. In contrast, the cardiac secretion of BNP was fairly constant and rather significantly decreased in HCM (P < 0.01). The cardiac ANP secretion was significantly correlated with changes in LER (r = ?0.57, P < 0.01) and tau (r = 0.73, P < 0.001) in HCM patients. Tachycardia potentiates the cardiac secretion of ANP, not BNP, in patients with HCM, particularly when it induces myocardial ischemia and LV diastolic dysfunction. |
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言語 |
en |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
Kido, S; Hasebe, N; Ishii, Y; Kikuchi, K, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 290(3), H1064-H1070, 2006. "Copyright 2006 by the American Physical Society."publisher |
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言語 |
en |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
VoR |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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16172169 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1321 |
222.pdf (173.1 kB)
