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Unequal effects of renin-angiotensin system inhibitors in acute cardiac dysfunction induced by isoproterenol
https://asahikawa-med.repo.nii.ac.jp/records/3323
https://asahikawa-med.repo.nii.ac.jp/records/3323c688cf5e-1d8a-41d0-a045-dcbd2715067e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
207.pdf (275.1 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
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| 公開日 | 2007-02-14 | |||||
| タイトル | ||||||
| タイトル | Unequal effects of renin-angiotensin system inhibitors in acute cardiac dysfunction induced by isoproterenol | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
太田, 貴文
× 太田, 貴文× Hasebe, N× Tsuji, S× Izawa, K× Kido, S× Natori, S× Sato, M× Kikuchi, K |
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| 著者 ローマ字 | ||||||
| 値 | Ohta, Takafumi | |||||
| 著者 ローマ字 | ||||||
| 言語 | en | |||||
| 書誌情報 |
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 巻 287, 号 6, p. H2914-H2921, 発行日 2004-12-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0363-6135 | |||||
| リンクURL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://ajpheart.physiology.org/cgi/content/abstract/287/6/H2914?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=287&firstpage=H2914&resourcetype=HWCIT | http://ajpheart.physiology.org/cgi/content/abstract/287/6/H2914?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=287&firstpage=H2914&resourcetype=HWCIT | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Several clinical trials have demonstrated that angiotensin-converting enzyme inhibitor (ACEI) and angiotensin II type 1 receptor blocker (ARB) are equally effective in the treatment of chronic heart failure. However, this has not been confirmed for acute cardiac dysfunction. We examined whether ACEI or ARB prevents isoproterenol-induced acute left ventricular (LV) dysfunction in dogs. LV dysfunction induced by a large dose of isoproterenol (1 μg・kg^?1・min^?1, 3-h infusion) was compared in dogs treated with ACEI (temocaprilat) or ARB (olmesartan). Atrial pacing induced a constant heart rate and use of adjustable aortic banding provided a nearly constant afterload. LV systolic function (LV dP/dt, fractional shortening, and ejection fraction) and diastolic function (γ and LV end-diastolic pressure) were significantly deteriorated after isoproterenol infusion. The LV dysfunction was almost totally prevented by ARB but was only partially prevented by ACEI. The partial effect of ACEI was complemented by cotreatment with HOE-140, a bradykinin B_2 receptor antagonist. At baseline, the response to low doses of isoproterenol was significantly attenuated by ACEI but not by ARB, and the ACEI-induced attenuation was totally abolished by cotreatment with HOE-140. The response to isoproterenol was significantly attenuated after 3 h of excess isoproterenol loading, and it was almost completely preserved by ARB but not by ACEI. In conclusion, acute LV dysfunction and β-adrenergic desensitization induced by excess isoproterenol administration were almost totally prevented by ARB but only partially prevented by ACEI. These differences were attributable at least in part to bradykinin pathways activated by ACEI administration in acute LV dysfunction. | |||||
| 言語 | en | |||||
| 注記 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Ohta, T; Hasebe, N; Tsuji, S; Izawa, K; Jin, YT; Kido, S; Natori, S; Sato, M; Kikuchi, K, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 287(6), H2914-H2921, 2004. "Copyright 2004 by the American Physical Society." \npublisher |
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| 言語 | en | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | text | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| ID(XooNIps) | ||||||
| 値 | 15297251 | |||||
| 閲覧数(XooNIps) | ||||||
| 値 | 1443 | |||||
| ダウンロード数(XooNIps) | ||||||
| 値 | 1868 | |||||
