| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2007-03-22 |
| タイトル |
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タイトル |
A selective orexin-1 receptor antagonist, SB334867, blocks 2-DG-induced gastric acid secretion in rats |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
奥村, 利勝
Yamada, H
Takahashi, N
Tanno, S
Nagamine, M
Takakusaki, K
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| 著者 ローマ字 |
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Okumura, Toshikatsu |
| 書誌情報 |
NEUROSCIENCE LETTERS
巻 376,
号 2,
p. 137-142,
発行日 2005-03-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0304-3940 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.neulet.2004.11.043 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://www.sciencedirect.com/science/journal/03043940 | http://www.sciencedirect.com/science/journal/03043940 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
We have previously demonstrated that intracisternal orexin-A potently stimulated gastric acid secretion through the vagus nerve. Considering its stimulatory action on feeding, we hypothesized that orexin-A is a candidate mediator of cephalic phase gastric secretion. It has also been suggested that the stimulation of acid by central orexin-A may be mediated by orexin 1 receptor (OX_1R) in the brain. In the present study, we tried to clarify whether endogenously released orexin-A in the brain indeed plays a physiological role in gastric secretion. To address the question, the effects of OX1R antagonist on gastric acid secretion was examined in rats. Intraperitoneal administration of SB334867, a specific OX_1R anatagonist, by itself did not change gastric acid secretion in pylorus-ligated conscious rats. Pretreatment with SB334867 in a dose of 10 mg/kg completely blocked the stimulated acid output by intracisternal orexin-A but not thyrotropin-releasing hormone, suggesting that SB334867 specifically blocked the action of orexin-A in the brain. 2-deoxy-D-glucose (2-DG) -induced stimulation of gastric acid output was significantly blocked by pretreatment with intraperitoneal administration of SB334867. These results suggest that endogenously released orexin-A in the brain plays a vital role in central regulation of gastric secretion. Since 2-DG induces central glucoprivation as a hunger state, the present study furthermore support the speculation that orexin-A may be an important molecule that triggers the cephalic phase gastric aicd secretion. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
ELSEVIER, Yamada, H; Takahashi, N; Tanno, S; Nagamine, M; Takakusaki, K; Okumura, T, NEUROSCIENCE LETTERS, 376(2), 137-142, 2005.
\nauthor |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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15698936 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1384 |
379.pdf (268.0 kB)
