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A selective orexin-1 receptor antagonist, SB334867, blocks 2-DG-induced gastric acid secretion in rats
https://asahikawa-med.repo.nii.ac.jp/records/304
https://asahikawa-med.repo.nii.ac.jp/records/30453c9dceb-e411-4d1a-91bf-6ca85465a1f2
| 名前 / ファイル | ライセンス | アクション |
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379.pdf (268.0 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||||||||
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| 公開日 | 2007-03-22 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | A selective orexin-1 receptor antagonist, SB334867, blocks 2-DG-induced gastric acid secretion in rats | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| 著者 |
奥村, 利勝
× 奥村, 利勝
× Yamada, H
× Takahashi, N
× Tanno, S
× Nagamine, M
× Takakusaki, K
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| 著者 ローマ字 | ||||||||||||||||||||
| Okumura, Toshikatsu | ||||||||||||||||||||
| 書誌情報 |
NEUROSCIENCE LETTERS 巻 376, 号 2, p. 137-142, 発行日 2005-03-01 |
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| ISSN | ||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||
| 収録物識別子 | 0304-3940 | |||||||||||||||||||
| DOI | ||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | 10.1016/j.neulet.2004.11.043 | |||||||||||||||||||
| リンクURL | ||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||
| 内容記述 | http://www.sciencedirect.com/science/journal/03043940 | http://www.sciencedirect.com/science/journal/03043940 | |||||||||||||||||||
| 抄録 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | We have previously demonstrated that intracisternal orexin-A potently stimulated gastric acid secretion through the vagus nerve. Considering its stimulatory action on feeding, we hypothesized that orexin-A is a candidate mediator of cephalic phase gastric secretion. It has also been suggested that the stimulation of acid by central orexin-A may be mediated by orexin 1 receptor (OX_1R) in the brain. In the present study, we tried to clarify whether endogenously released orexin-A in the brain indeed plays a physiological role in gastric secretion. To address the question, the effects of OX1R antagonist on gastric acid secretion was examined in rats. Intraperitoneal administration of SB334867, a specific OX_1R anatagonist, by itself did not change gastric acid secretion in pylorus-ligated conscious rats. Pretreatment with SB334867 in a dose of 10 mg/kg completely blocked the stimulated acid output by intracisternal orexin-A but not thyrotropin-releasing hormone, suggesting that SB334867 specifically blocked the action of orexin-A in the brain. 2-deoxy-D-glucose (2-DG) -induced stimulation of gastric acid output was significantly blocked by pretreatment with intraperitoneal administration of SB334867. These results suggest that endogenously released orexin-A in the brain plays a vital role in central regulation of gastric secretion. Since 2-DG induces central glucoprivation as a hunger state, the present study furthermore support the speculation that orexin-A may be an important molecule that triggers the cephalic phase gastric aicd secretion. | |||||||||||||||||||
| 注記 | ||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||
| 注記 | ELSEVIER, Yamada, H; Takahashi, N; Tanno, S; Nagamine, M; Takakusaki, K; Okumura, T, NEUROSCIENCE LETTERS, 376(2), 137-142, 2005. \nauthor |
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| 資源タイプ | ||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||
| 資源タイプ | text | |||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||||||
| ID(XooNIps) | ||||||||||||||||||||
| 15698936 | ||||||||||||||||||||
| 閲覧数(XooNIps) | ||||||||||||||||||||
| ダウンロード数(XooNIps) | ||||||||||||||||||||
| 1384 | ||||||||||||||||||||
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奥村, 利勝, Yamada, H, Takahashi, N, Tanno, S, Nagamine, M, Takakusaki, K, n.d., A selective orexin-1 receptor antagonist, SB334867, blocks 2-DG-induced gastric acid secretion in rats: 137–142 p.
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